ArticleClinical and experimental immunology2006
High prevalence of mannose-binding lectin (MBL) deficiency in premature neonates.
Article in Clinical and experimental immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 75 citations in OpenAlex.
- Clinical associations of complement-activating collectins, collectin-10, collectin-11 and mannose-binding lectin in preterm neonates.Frontiers in immunology · 2024Article
- Biomarkers of necrotizing enterocolitis in the era of machine learning and omics.Seminars in perinatology · 2023Review
- Collectins and ficolins in neonatal health and disease.Frontiers in immunology · 2023Review
- Association of theInternational journal of molecular sciences · 2022Article
- High normal TSH is associated with lower mannan-binding lectin in women of childbearing age.BMC endocrine disorders · 2020Article
- Preparing for Life: Plasma Proteome Changes and Immune System Development During the First Week of Human Life.Frontiers in immunology · 2020Article
- Mannose Binding Lectin, S100 B Protein, and Brain Injuries in Neonates With Perinatal Asphyxia.Frontiers in pediatrics · 2020Article
- Use of Mannose-Binding Lectin Gene Polymorphisms and the Serum MBL Level for the Early Detection of Neonatal Sepsis.Journal of pediatric genetics · 2018Article
- Mannose-binding lectin and mannose-binding protein-associated serine protease 2 levels and infection in very-low-birth-weight infants.Pediatric research · 2018Article
- Autosomal dominant mannose-binding lectin deficiency is associated with worse neurodevelopmental outcomes after cardiac surgery in infants.The Journal of thoracic and cardiovascular surgery · 2018Article
- Antimicrobial peptide LL-37 and recombinant human mannose-binding lectin express distinct age- and pathogen-specific antimicrobial activity in human newborn cord bloodF1000Research · 2018Article
- The association of mannose-binding lectin 2 polymorphisms with outcome in very low birth weight infants.PloS one · 2017Article
- MBL2 genotypes and their associations with MBL levels and NICU morbidity in a cohort of Greek neonates.Journal of immunology research · 2015Article
- A two-nucleotide deletion renders the mannose-binding lectin 2 (MBL2) gene nonfunctional in Danish Landrace and Duroc pigs.Immunogenetics · 2014Article
- Soluble mediators regulating immunity in early life.Frontiers in immunology · 2014Review
- Role of innate immunity in neonatal infection.American journal of perinatology · 2013Review
- The developing human preterm neonatal immune system: a case for more research in this area.Clinical immunology (Orlando, Fla.) · 2012Review
- Serum mannose-binding lectin (MBL) gene polymorphism and low MBL levels are associated with neonatal sepsis and pneumonia.Journal of perinatology : official journal of the California Perinatal Association · 2012Article
- Factors of the lectin pathway of complement activation and their clinical associations in neonates.Journal of biomedicine & biotechnology · 2012Review
- Mannose-binding lectin deficiency with eosinophilic meningoencephalitis due to Angiostrongylus cantonensis in children: a case series.Journal of medical case reports · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mannose-binding lectin (MBL) is a component of innate immunity and thus particularly important in neonates in whom adaptive immunity is not yet completely developed. Promoter polymorphisms and structural exon-1 mutations in the MBL2 gene cause reduced or deficient MBL plasma concentrations. The aim of our study was to determine the prevalence of MBL deficiency in neonates admitted to the neonatal intensive care unit (NICU). Eighty-five NICU patients (69 premature) were included in the study. We measured MBL concentrations in umbilical cord and neonatal blood within 24 h after birth by ELISA technique. MBL2 genotypes (n = 67) were determined by Taqman analysis. MBL concentrations were measured longitudinally during three weeks in 26 premature neonates. The association between pre- and intra-partum clinical data and MBL concentrations was investigated. At birth, 29 (42%) premature and six (38%) term neonates had MBL plasma concentrations < or = 0.7 microg/ml which was regarded as deficient. Twenty-one (38%) premature and four (36%) term neonates had variant MBL2 haplotypes, corresponding to exon-1 mutations and the LXPA haplotype. MBL concentrations increased over time in neonates with wild-type MBL2 haplotypes, but not in neonates with variant haplotypes. Low MBL plasma concentrations were related to lower gestational age and variant MBL2 haplotypes. Umbilical cord and neonatal MBL plasma concentrations appeared to be similar. In conclusion, almost half of our NICU patients, especially the premature ones, were MBL-deficient at birth. These infants may be at increased risk of neonatal infections. MBL concentration can reliably be measured in umbilical cord blood and it is positively correlated with gestational and postnatal age.
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Registered trials
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