ArticleDNA and cell biology2006
Increased recombination between active tRNA genes.
Article in DNA and cell biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
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- Frequent genetic exchanges revealed by a pan-mitogenome graph of a fungal plant pathogen.mBio · 2024Article
- Discovery of a rapidly evolving yeast defense factor,Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- APOBEC3B cytidine deaminase targets the non-transcribed strand of tRNA genes in yeast.DNA repair · 2017Article
- Genetic instability in budding and fission yeast-sources and mechanisms.FEMS microbiology reviews · 2015Review
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- tRNAomics: tRNA gene copy number variation and codon use provide bioinformatic evidence of a new anticodon:codon wobble pair in a eukaryote.RNA (New York, N.Y.) · 2012Article
- Additions, losses, and rearrangements on the evolutionary route from a reconstructed ancestor to the modern Saccharomyces cerevisiae genome.PLoS genetics · 2009Article
- Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Clustering of yeast tRNA genes is mediated by specific association of condensin with tRNA gene transcription complexes.Genes & development · 2008Article
- Tissue invasion by Entamoeba histolytica: evidence of genetic selection and/or DNA reorganization events in organ tropism.PLoS neglected tropical diseases · 2008Article
- Patterns of evolution in the unique tRNA gene arrays of the genus Entamoeba.Molecular biology and evolution · 2008Article
- Myc dynamically and preferentially relocates to a transcription factory occupied by Igh.PLoS biology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Transfer RNA genes are distributed throughout eukaryotic genomes, and are frequently found as multicopy families. In Saccharomyces cerevisiae, tRNA gene transcription by RNA polymerase III suppresses nearby transcription by RNA polymerase II, partially because the tRNA genes are clustered near the nucleolus. We have tested whether active transcription of tRNA genes might also suppress recombination, since recombination between identical copies of the repetitive tRNA genes could delete intervening genes and be detrimental to survival. The opposite proved to be the case. Recombination between active tRNA genes was elevated, but only when both genes are transcribed. We also tested the effects of tRNA genes on recombination between the direct terminal repeats of a neighboring retrotransposon, since most Ty retrotransposons reside next to tRNA genes, and the selective advantage of this arrangement is not known.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.