ArticleInfection and immunity2006
Effect of a CD4-depleting antibody on the development of Cryptococcus neoformans-induced allergic bronchopulmonary mycosis in mice.
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Interleukin-10 limits immune-mediated pathology in chronic subclinical plasmodial infection.PLoS neglected tropical diseases · 2025Article
- IL-10 production by granulocytes promotes Staphylococcus aureus craniotomy infection.Journal of neuroinflammation · 2023Article
- Anti-PD-1 Antibody Treatment Promotes Clearance of Persistent Cryptococcal Lung Infection in Mice.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- T Cells Regulate Peripheral Naive Mature B Cell Survival by Cell-Cell Contact Mediated through SLAMF6 and SAP.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Antibody-dependent fragmentation is a newly identified mechanism of cell killing in vivo.Scientific reports · 2017Article
- Low-Dose Intestinal Trichuris muris Infection Alters the Lung Immune Microenvironment and Can Suppress Allergic Airway Inflammation.Infection and immunity · 2016Article
- T Cells Exacerbate Lyme Borreliosis in TLR2-Deficient Mice.Frontiers in immunology · 2016Article
- In Vitro Analysis of Metabolites Secreted during Infection of Lung Epithelial Cells by Cryptococcus neoformans.PloS one · 2016Article
- Cryptococcus neoformans-induced macrophage lysosome damage crucially contributes to fungal virulence.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Article
- A live-attenuated pneumococcal vaccine elicits CD4+ T-cell dependent class switching and provides serotype independent protection against acute otitis media.EMBO molecular medicine · 2014Article
- IL-23 dampens the allergic response to Cryptococcus neoformans through IL-17-independent and -dependent mechanisms.The American journal of pathology · 2012Article
- Conventional dendritic cells are required for the activation of helper-dependent CD8 T cell responses to a model antigen after cutaneous vaccination with lentiviral vectors.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Dual roles of CD40 on microbial containment and the development of immunopathology in response to persistent fungal infection in the lung.The American journal of pathology · 2010Article
- Th2 but not Th1 immune bias results in altered lung functions in a murine model of pulmonary Cryptococcus neoformans infection.Infection and immunity · 2009Article
- Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Cryptococcal urease promotes the accumulation of immature dendritic cells and a non-protective T2 immune response within the lung.The American journal of pathology · 2009Article
- Enhanced innate immune responsiveness to pulmonary Cryptococcus neoformans infection is associated with resistance to progressive infection.Infection and immunity · 2008Article
- Pulmonary arterial remodeling induced by a Th2 immune response.The Journal of experimental medicine · 2008Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Allergic bronchopulmonary mycosis (ABPM) is a hypersensitivity lung disease in which fungal colonization is accompanied by an allergic response to the fungus. Using a mouse model of ABPM caused by Cryptococcus neoformans infection of C57BL/6 mice, the goal of the present studies was to determine the effect of the CD4-depleting monoclonal antibody GK1.5 on the development of the allergic responses seen during active fungal infection. These results would provide insight into the role of CD4(+) T cells in this disease. Our results show that GK1.5 treatment resulted in attenuation of pulmonary inflammation and eosinophilia in these animals. These mice also had reduced T2 cytokine production and no serum immunoglobulin E production. Absence of CD4(+) T cells did not affect recruitment of CD8(+) T cells to the site of infection; however, the numbers of CD19(+) B cells were severely reduced in the lungs of CD4(+) T-cell-depleted animals. We also examined changes in the pulmonary architecture and found that depletion of CD4(+) T cells was associated with a significant reduction in mucus production and goblet cell metaplasia in these mice. Interestingly, attenuation of Th2 responses in CD4(+) T-cell-depleted animals did not increase the fungal load in their lungs. We also compared development of ABPM in young and mature mice and did not find any differences at any of the time points. Overall, our results show that depletion of CD4(+) T cells prevents the development of Th2 responses seen during ABPM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.