ArticleInfection and immunity2006
cDNA microarray analysis of host-pathogen interactions in a porcine in vitro model for Toxoplasma gondii infection.
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Glancing at the role of Toxoplasma gondii in neuro-oncology: from risk factor to therapeutic target.Infectious agents and cancer · 2026Review
- Identification of Differentially Up-regulated Genes in Apple with White Rot Disease.The plant pathology journal · 2019Article
- Global Transcriptome Profiling of Multiple Porcine Organs RevealsFrontiers in immunology · 2019Article
- Rottlerin-mediated inhibition of Toxoplasma gondii growth in BeWo trophoblast-like cells.Scientific reports · 2017Article
- Activity of Fluorine-Containing Analogues of WC-9 and Structurally Related Analogues against Two Intracellular Parasites: Trypanosoma cruzi and Toxoplasma gondii.ChemMedChem · 2016Article
- Recombinant Toxoplasma gondii phosphoglycerate mutase 2 confers protective immunity against toxoplasmosis in BALB/c mice.Parasite (Paris, France) · 2016Article
- Possible role of Toxoplasma gondii in brain cancer through modulation of host microRNAs.Infectious agents and cancer · 2013Article
- Toxoplasma gondii relies on both host and parasite isoprenoids and can be rendered sensitive to atorvastatin.PLoS pathogens · 2013Article
- Gene expression profiles in genetically different mice infected with Toxoplasma gondii: ALDH1A2, BEX2, EGR2, CCL3 and PLAU.The Korean journal of parasitology · 2012Article
- Differential gene expression in mice infected with distinct Toxoplasma strains.Infection and immunity · 2012Article
- Toxoplasma gondii down modulates cadherin expression in skeletal muscle cells inhibiting myogenesis.BMC microbiology · 2011Article
- Methods for transcriptomic analyses of the porcine host immune response: application to Salmonella infection using microarrays.Veterinary immunology and immunopathology · 2010Review
- Advances in swine transcriptomics.International journal of biological sciences · 2007Review
- Microarray-based transcriptional profiling of Eimeria bovis-infected bovine endothelial host cells.Veterinary researchArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Toxoplasma gondii induces the expression of proinflammatory cytokines, reorganizes organelles, scavenges nutrients, and inhibits apoptosis in infected host cells. We used a cDNA microarray of 420 annotated porcine expressed sequence tags to analyze the molecular basis of these changes at eight time points over a 72-hour period in porcine kidney epithelial (PK13) cells infected with T. gondii. A total of 401 genes with Cy3 and Cy5 spot intensities of >/=500 were selected for analysis, of which 263 (65.6%) were induced >/=2-fold (expression ratio, >/=2.0; P </= 0.05 [t test]) over at least one time point and 48 (12%) were significantly down-regulated. At least 12 functional categories of genes were modulated (up- or down-regulated) by T. gondii. The majority of induced genes were clustered as transcription, signal transduction, host immune response, nutrient metabolism, and apoptosis related. The expression of selected genes altered by T. gondii was validated by quantitative real-time reverse transcription-PCR. These results suggest that significant changes in gene expression occur in response to T. gondii infection in PK13 cells, facilitating further analysis of host-pathogen interactions in toxoplasmosis in a secondary host.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.