ArticleInfection and immunity2006
Expression of putative virulence factors of Escherichia coli O157:H7 differs in bovine and human infections.
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 56 citations in OpenAlex.
- The interactions of bacteriophage Ace and Shiga toxin-producing Escherichia coli during biocontrol.FEMS microbiology ecology · 2021Article
- Shiga Toxin-Producing E. coli in Animals: Detection, Characterization, and Virulence Assessment.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Nonfimbrial Adhesin Mutants Reveal DivergentInternational journal of microbiology · 2021Article
- The Role ofToxins · 2020Review
- Metabolic Traits of Bovine Shiga Toxin-ProducingToxins · 2020Article
- Animal models of hospital-acquired pneumonia: current practices and future perspectives.Annals of translational medicine · 2017Review
- A Rapid Immunoassay for Detection of Shiga Toxin-Producing Escherichia coli Directly from Human Fecal Samples and Its Performance in Detection of Toxin Subtypes.Journal of clinical microbiology · 2016Article
- Cell-Free Spent Media Obtained fromFrontiers in microbiology · 2016Article
- Article
- Differences in virulence gene expression between atypical enteropathogenic Escherichia coli strains isolated from diarrheic and healthy ruminants.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2013Article
- Enterohemorrhagic Escherichia coli hemolysin employs outer membrane vesicles to target mitochondria and cause endothelial and epithelial apoptosis.PLoS pathogens · 2013Article
- Identification of a novel prophage regulator in Escherichia coli controlling the expression of type III secretion.Molecular microbiology · 2012Article
- Virulence inhibition by zinc in shiga-toxigenic Escherichia coli.Infection and immunity · 2011Article
- Differential gene expression and adherence of Escherichia coli O157:H7 in vitro and in ligated pig intestines.PloS one · 2011Article
- A method for isolating and analyzing human mRNA from newborn stool.Journal of immunological methods · 2009Article
- Adherence of Escherichia coli O157:H7 mutants in vitro and in ligated pig intestines.Applied and environmental microbiology · 2009Article
- Escherichia coli O157:H7 strain origin, lineage, and Shiga toxin 2 expression affect colonization of cattle.Applied and environmental microbiology · 2009Article
- Article
- Genomic instability in regions adjacent to a highly conserved pch prophage in Escherichia coli O157:H7 generates diversity in expression patterns of the LEE pathogenicity island.Journal of bacteriology · 2009Article
- Enterohemorrhagic Escherichia coli O157:H7 gene expression profiling in response to growth in the presence of host epithelia.PloS one · 2009Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Escherichia coli O157:H7 is a commensal organism in cattle, but it is a pathogen in humans. This differential expression of virulence suggests that specific virulence factors are regulated differently in human and bovine hosts. To test this hypothesis, relative real-time reverse transcription-PCR was used to relate the expression of several putative virulence genes (eae, espA, stx(2), rfbE, ehxA, and iha) to that of the "housekeeping" gene gnd during natural human and experimental bovine infection with E. coli O157:H7. We examined these genes in fecal samples from eight humans and four calves. iha and espA were significantly more expressed in bovine infections. rfbE and ehxA appeared to be more highly expressed in human infections, though these differences did not achieve statistical significance. Our results support the hypothesis that some virulence-associated genes of O157:H7 are differentially expressed in a host-specific manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.