ArticleInfection and immunity2006
Role of sigma E-regulated genes in Escherichia coli uropathogenesis.
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
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- Genome-Wide Identification of Fitness Factors in Mastitis-Associated Escherichia coli.Applied and environmental microbiology · 2018Article
- Virulence and Fitness Determinants of Uropathogenic Escherichia coli.Microbiology spectrum · 2015Review
- Analysis of the link between the redox state and enzymatic activity of the HtrA (DegP) protein from Escherichia coli.PloS one · 2015Article
- dsdA Does Not Affect Colonization of the Murine Urinary Tract by Escherichia coli CFT073.PloS one · 2015Article
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- Genetic analysis of the role of yfiR in the ability of Escherichia coli CFT073 to control cellular cyclic dimeric GMP levels and to persist in the urinary tract.Infection and immunity · 2013Article
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- Chemoreceptors of Escherichia coli CFT073 play redundant roles in chemotaxis toward urine.PloS one · 2013Article
- Kinetics of uropathogenic Escherichia coli metapopulation movement during urinary tract infection.mBio · 2012Article
- Identification of potential therapeutic targets for Burkholderia cenocepacia by comparative transcriptomics.PloS one · 2010Article
- Survival of uropathogenic Escherichia coli in the murine urinary tract is dependent on OmpR.Microbiology (Reading, England) · 2009Article
- Uropathogenic Escherichia coli CFT073 is adapted to acetatogenic growth but does not require acetate during murine urinary tract infection.Infection and immunity · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The sigma E regulon encodes proteins for maintenance and repair of the Escherichia coli cell envelope. Previously, we observed that an antirepressor of sigma E, DegS, is essential for uropathogenic E. coli virulence. Here we use a mouse urinary tract infection model to assay the virulence of mutants of E. coli genes described as sigma E dependent. Deletion mutants of candidate genes were made in the uropathogenic E. coli strain CFT073. Swiss Webster female mice were inoculated with a mixture of mutant and wild-type strains. Bladder and kidney homogenates were cultured 2 days after infection, and CFU of the wild type and mutant were compared. Eleven mutants were assayed, and two, CFT073 degP and CFT073 skp, showed significantly diminished survival compared to wild type. DegP is a chaperone and degradase active in the periplasm. Skp is also a periplasmic chaperone. The virulence of the skp deletion mutant could not be restored by complementation with skp. The virulence of the degP deletion mutant, in contrast, could be restored. However, complementation with a degP allele encoding a serine-to-alanine (S210A) mutation at the protease active site fails to restore virulence. Unlike degP mutants in other bacteria, the E. coli degP mutant is tolerant of oxidative stress. It disappears abruptly from bladder and kidney cultures between 6 and 12 hours after inoculation. A mutant of degQ, a close homolog of degP, was not attenuated in mice. This is the first report that the DegP degradase is an E. coli virulence factor in an animal infection model.
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