ArticleInfection and immunity2006
LuxS involvement in the regulation of genes coding for hemin and iron acquisition systems in Porphyromonas gingivalis.
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed, 107 citations in OpenAlex.
- Illuminating the mechanism: gene expression responses to antimicrobial photodynamic therapy.BMC genomics · 2026Review
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- Transcriptional modulation of Porphyromonas gingivalis biofilms on titanium-copper implant surfaces.Folia microbiologica · 2025Article
- Antimicrobial Peptides: A Promising Alternative to Conventional Antimicrobials for Combating Polymicrobial Biofilms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Hypochlorous acid solution serves as a potential anti-biofilm therapy for periodontitisJournal of oral microbiology · 2025Article
- Understanding Quorum-Sensing and Biofilm Forming in Anaerobic Bacterial Communities.International journal of molecular sciences · 2024Review
- Phage-based biocontrol ofApplied and environmental microbiology · 2024Article
- Hemophore-like proteins of the HmuY family in the oral and gut microbiome: unraveling the mystery of their evolution.Microbiology and molecular biology reviews : MMBR · 2024Review
- Curcumin inhibits growth ofJournal of oral microbiology · 2024Article
- Gum Arabic as a potential candidate in quorum quenching and treatment of periodontal diseases.Frontiers in oral health · 2024Review
- Hemin availability induces coordinated DNA methylation and gene expression changes inmSystems · 2023Article
- Drugs for the Quorum Sensing Inhibition of Oral Biofilm: New Frontiers and Insights in the Treatment of Periodontitis.Pharmaceutics · 2022Review
- A unique bacterial secretion machinery with multiple secretion centers.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Anti-biofilm activities of coumarin as quorum sensing inhibitor forJournal of oral microbiology · 2022Article
- Identification and characterization of a UbK family kinase in Porphyromonas gingivalis that phosphorylates the RprY response regulator.Molecular oral microbiology · 2021Article
- Soft Materials that Intercept, Respond to, and Sequester Bacterial Siderophores.Chemistry of materials : a publication of the American Chemical Society · 2021Article
- Ecological Role of Volatile Organic Compounds Emitted byMicroorganisms · 2021Article
- LuxS quorum sensing system and biofilm formation of oral microflora: A short review article.The Saudi dental journal · 2021Review
- Research progress on two-component signal transduction systems inHua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2021Review
- A Novel Small Molecule, 1,3-di-m-tolyl-urea, Inhibits and Disrupts Multispecies Oral Biofilms.Microorganisms · 2020Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 2 institutions in 1 country.
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Abstract
The periodontal pathogen Porphyromonas gingivalis employs a variety of mechanisms for the uptake of hemin and inorganic iron. Previous work demonstrated that hemin uptake in P. gingivalis may be controlled by LuxS-mediated signaling. In the present study, the expression of genes involved in hemin and iron uptake was determined in parent and luxS mutant strains by quantitative real-time reverse transcription-PCR. Compared to the parental strain, the luxS mutant showed reduced levels of transcription of genes coding for the TonB-linked hemin binding protein Tlr and the lysine-specific protease Kgp, which can degrade host heme-containing proteins. In contrast, there was up-regulation of the genes for another TonB-linked hemin binding protein, HmuR; a hemin binding lipoprotein, FetB; a Fe(2+) ion transport protein, FeoB1; and the iron storage protein ferritin. Differential expression of these genes in the luxS mutant was maximal in early-exponential phase, which corresponded with peak expression of luxS and AI-2 signal activity. Complementation of the luxS mutation with wild-type luxS in trans rescued expression of hmuR. Mutation of the GppX two-component signal transduction pathway caused an increase in expression of luxS along with tlr and lower levels of message for hmuR. Moreover, expression of hmuR was repressed, and expression of tlr stimulated, when the luxS mutant was incubated with AI-2 partially purified from the culture supernatant of wild-type cells. A phenotypic outcome of the altered expression of genes involved in hemin uptake was impairment of growth of the luxS mutant in hemin-depleted medium. The results demonstrate a role of LuxS/AI-2 in the regulation of hemin and iron acquisition pathways in P. gingivalis and reveal a novel control pathway for luxS expression.
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