Evidence map›Paper›PMID 16790484›Full record

Trial reportBritish journal of sports medicine2006

Efficacy of a tart cherry juice blend in preventing the symptoms of muscle damage.

D A J Connolly, M P McHugh, O I Padilla-Zakour, L Carlson, S P Sayers

2 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British journal of sports medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 113 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
113citing papers in PubMed, 7 pooled it
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00443092 phase4completednot on this mapstarted 2007, after this paper: background citation

A Double Blind Cross-over Study of the Efficacy of a Proprietary Cherry Juice Blend in Osteoarthritis of the Knee.

TypeinterventionalSponsorCherryPharmRan2007 to 2010Enrolled59ConditionsOsteoarthritisArmsproprietary cherry juice blend (food), control juice (kool aid blend)
NCT07224867 nawithdrawnnot on this mapstarted 2026, after this paper: background citation

The Effects of Liquid IV's Multi-Ingredient Recovery Supplement, on Muscle Recovery Following Exercise: A Randomized Crossover Study

TypeinterventionalSponsorApplied Science & Performance InstituteRan2026 to 2027Enrolled0ConditionsMuscle Damage, Strength Recovery, Perceived Recovery, Perceived Muscle SorenessArmsproprietary post workout recovery supplement, Control placebo
3 · Its place in the literature

Who cites it

113 citing papers in PubMed, 7 syntheses or guidelines pooled it, 265 citations in OpenAlex.

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  7. Antioxidants for preventing and reducing muscle soreness after exercise.The Cochrane database of systematic reviews · 2017
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53 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

D A J ConnollyHuman Performance Laboratory, University of Vermont, Burlington, VT 05405, USA. Declan.Connolly@uvm.edu
M P McHugh
O I Padilla-Zakour
L Carlson
S P Sayers
Cornell University · USLenox Hill Hospital · USUniversity of Vermont · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNumerous antioxidant and anti-inflammatory agents have been identified in tart cherries.

objectiveTo test the efficacy of a tart cherry juice blend in preventing the symptoms of exercise induced muscle damage.

methodsThis was a randomised, placebo controlled, crossover design. Fourteen male college students drank 12 fl oz of a cherry juice blend or a placebo twice a day for eight consecutive days. A bout of eccentric elbow flexion contractions (2 x 20 maximum contractions) was performed on the fourth day of supplementation. Isometric elbow flexion strength, pain, muscle tenderness, and relaxed elbow angle were recorded before and for four days after the eccentric exercise. The protocol was repeated two weeks later with subjects who took the placebo initially, now taking the cherry juice (and vice versa). The opposite arm performed the eccentric exercise for the second bout to avoid the repeated bout protective effect.

resultsStrength loss and pain were significantly less in the cherry juice trial versus placebo (time by treatment: strength p<0.0001, pain p = 0.017). Relaxed elbow angle (time by treatment p = 0.85) and muscle tenderness (time by treatment p = 0.81) were not different between trials.

conclusionsThese data show efficacy for this cherry juice in decreasing some of the symptoms of exercise induced muscle damage. Most notably, strength loss averaged over the four days after eccentric exercise was 22% with the placebo but only 4% with the cherry juice.

Indexed as

FruitPhytotherapyPrunusAdolescentAdultBiomechanical PhenomenaCross-Over StudiesElbowElbow InjuriesExerciseHumansMaleMuscle ContractionMuscle, SkeletalPlant PreparationsPlant Preparations

Identifiers

PMID16790484
PMCPMC2579450
OpenAlexW2096711874

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.