ArticlePLoS genetics2006
Genetic screens for mutations affecting development of Xenopus tropicalis.
Article in PLoS genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 70 citations in OpenAlex.
- Producing Gynogenetic Embryos in Xenopus tropicalis.Methods in molecular biology (Clifton, N.J.) · 2026Article
- CRISPR/Cas9 Gene Disruption Studies in FMethods in molecular biology (Clifton, N.J.) · 2023Article
- Picroscope: low-cost system for simultaneous longitudinal biological imaging.Communications biology · 2021Article
- Deep learning is widely applicable to phenotyping embryonic development and disease.Development (Cambridge, England) · 2021Article
- Hybridization promotes asexual reproduction in Caenorhabditis nematodes.PLoS genetics · 2019Article
- Transient window of resilience during early development minimizes teratogenic effects of heat in zebrafish embryos.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Article
- Paternal chromosome loss and metabolic crisis contribute to hybrid inviability in Xenopus.Nature · 2018Article
- Imaging MyelinationBrain plasticity (Amsterdam, Netherlands) · 2016Review
- The old and new face of craniofacial research: How animal models inform human craniofacial genetic and clinical data.Developmental biology · 2016Review
- Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels.Scientific reports · 2015Article
- Contractile activity is required for Z-disc sarcomere maturation in vivo.Genesis (New York, N.Y. : 2000) · 2015Article
- Xenopus mutant reveals necessity of rax for specifying the eye field which otherwise forms tissue with telencephalic and diencephalic character.Developmental biology · 2014Article
- Sp8 regulates inner ear development.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- RNA sequencing reveals a diverse and dynamic repertoire of the Xenopus tropicalis transcriptome over development.Genome research · 2013Article
- Exon capture and bulk segregant analysis: rapid discovery of causative mutations using high-throughput sequencing.BMC genomics · 2012Article
- Biomechanics of early cardiac development.Biomechanics and modeling in mechanobiology · 2012Article
- The hitchhiker's guide to Xenopus genetics.Genesis (New York, N.Y. : 2000) · 2012Review
- Xenopus tropicalis as a model organism for genetics and genomics: past, present, and future.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Genetic analysis of Xenopus tropicalis.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Xenopus research: metamorphosed by genetics and genomics.Trends in genetics : TIG · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We present here the results of forward and reverse genetic screens for chemically-induced mutations in Xenopus tropicalis. In our forward genetic screen, we have uncovered 77 candidate phenotypes in diverse organogenesis and differentiation processes. Using a gynogenetic screen design, which minimizes time and husbandry space expenditures, we find that if a phenotype is detected in the gynogenetic F2 of a given F1 female twice, it is highly likely to be a heritable abnormality (29/29 cases). We have also demonstrated the feasibility of reverse genetic approaches for obtaining carriers of mutations in specific genes, and have directly determined an induced mutation rate by sequencing specific exons from a mutagenized population. The Xenopus system, with its well-understood embryology, fate map, and gain-of-function approaches, can now be coupled with efficient loss-of-function genetic strategies for vertebrate functional genomics and developmental genetics.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.