ArticlePLoS computational biology2006
Moving forward moving backward: directional sorting of chemotactic cells due to size and adhesion differences.
Article in PLoS computational biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
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- Unraveling the effect of intra- and intercellular processes on acetaminophen-induced liver injury.NPJ systems biology and applications · 2022Article
- From energy to cellular forces in the Cellular Potts Model: An algorithmic approach.PLoS computational biology · 2019Article
- The biophysical nature of cells: potential cell behaviours revealed by analytical and computational studies of cell surface mechanics.BMC biophysics · 2015Article
- Article
- Skin stem cell hypotheses and long term clone survival--explored using agent-based modelling.Scientific reports · 2013Article
- Chemotactic migration of T cells towards dendritic cells promotes the detection of rare antigens.PLoS computational biology · 2012Article
- Study on multicellular systems using a phase field model.PloS one · 2012Article
- Multi-scale modeling in morphogenesis: a critical analysis of the cellular Potts model.PloS one · 2012Article
- Computational model of cell positioning: directed and collective migration in the intestinal crypt epithelium.Journal of the Royal Society, Interface · 2010Article
- Forming patterns in development without morphogen gradients: scattered differentiation and sorting out.Cold Spring Harbor perspectives in biology · 2009Review
- Simulation of single-species bacterial-biofilm growth using the Glazier-Graner-Hogeweg model and the CompuCell3D modeling environment.Mathematical biosciences and engineering : MBE · 2008Article
- Cell adhesion and cortex contractility determine cell patterning in the Drosophila retina.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Patterns of mesenchymal condensation in a multiscale, discrete stochastic model.PLoS computational biology · 2007Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Differential movement of individual cells within tissues is an important yet poorly understood process in biological development. Here we present a computational study of cell sorting caused by a combination of cell adhesion and chemotaxis, where we assume that all cells respond equally to the chemotactic signal. To capture in our model mesoscopic properties of biological cells, such as their size and deformability, we use the Cellular Potts Model, a multiscale, cell-based Monte Carlo model. We demonstrate a rich array of cell-sorting phenomena, which depend on a combination of mescoscopic cell properties and tissue level constraints. Under the conditions studied, cell sorting is a fast process, which scales linearly with tissue size. We demonstrate the occurrence of "absolute negative mobility", which means that cells may move in the direction opposite to the applied force (here chemotaxis). Moreover, during the sorting, cells may even reverse the direction of motion. Another interesting phenomenon is "minority sorting", where the direction of movement does not depend on cell type, but on the frequency of the cell type in the tissue. A special case is the cAMP-wave-driven chemotaxis of Dictyostelium cells, which generates pressure waves that guide the sorting. The mechanisms we describe can easily be overlooked in studies of differential cell movement, hence certain experimental observations may be misinterpreted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.