ArticlePsychopharmacology2006
Factors producing a menopausal depressive-like state in mice following ovariectomy.
Article in Psychopharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- EFFICACY OF ESTRADIOL IN PERIMENOPAUSAL DEPRESSION: SO MUCH PROMISE AND SO FEW ANSWERS.Depression and anxiety · 2015Pooled it
- Estradiol-mediated protection against high-fat diet induced anxiety and obesity is associated with changes in the gut microbiota in female mice.Scientific reports · 2023Article
- Estrogen, the Peripheral Immune System and Major Depression - A Reproductive Lifespan Perspective.Frontiers in behavioral neuroscience · 2022Review
- Osthole Ameliorates Estrogen Deficiency-Induced Cognitive Impairment in Female Mice.Frontiers in pharmacology · 2021Article
- Associations between estradiol and testosterone and depressive symptom scores of the Patient Health Questionnaire-9 in ovariectomized women: a population-based analysis of NHANES data.Annals of general psychiatry · 2020Article
- Ciliary neurotrophic factor is a key sex-specific regulator of depressive-like behavior in mice.Psychoneuroendocrinology · 2019Article
- Berberine produces antidepressant-like effects in ovariectomized mice.Scientific reports · 2017Article
- Ovariectomy results in inbred strain-specific increases in anxiety-like behavior in mice.Physiology & behavior · 2016Article
- Chronic exercise prevents repeated restraint stress-provoked enhancement of immobility in forced swimming test in ovariectomized mice.Metabolic brain disease · 2015Article
- Ovariectomy results in variable changes in nociception, mood and depression in adult female rats.PloS one · 2014Article
- Antidepressant-like effect of flaxseed secoisolariciresinol diglycoside in ovariectomized mice subjected to unpredictable chronic stress.Metabolic brain disease · 2013Article
- Effects of diphenyl diselenide on depressive-like behavior in ovariectomized mice submitted to subchronic stress: involvement of the serotonergic system.Psychopharmacology · 2012Article
- Progesterone attenuates depressive behavior of younger and older adult C57/BL6, wildtype, and progesterone receptor knockout mice.Pharmacology, biochemistry, and behavior · 2011Article
- Identification of antidepressant-like ingredients in ginseng root (Panax ginseng C.A. Meyer) using a menopausal depressive-like state in female mice: participation of 5-HT2A receptors.Psychopharmacology · 2011Article
- Progesterone receptor antagonist CDB-4124 increases depression-like behavior in mice without affecting locomotor ability.Psychoneuroendocrinology · 2011Article
- Progesterone reduces depressive behavior of young ovariectomized, aged progestin receptor knockout, and aged wild type mice in the tail suspension test.Journal of psychopharmacology (Oxford, England) · 2011Article
- Anhedonia in postpartum rats.Physiology & behavior · 2010Article
- Adult female wildtype, but not oestrogen receptor beta knockout, mice have decreased depression-like behaviour during pro-oestrus and following administration of oestradiol or diarylpropionitrile.Journal of psychopharmacology (Oxford, England) · 2009Article
- Role of nuclear factor kappaB in ovarian hormone-mediated stress hypersensitivity in female mice.Biological psychiatry · 2009Article
- Inhibition of progesterone metabolism mimics the effect of progesterone withdrawal on forced swim test immobility.Pharmacology, biochemistry, and behavior · 2007Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleBilateral ovariectomy in female mice produces a menopausal depressive-like state but the factors responsible for the phenomenon are unknown.
objectivesWe elucidated methodological issues related to establishing this mouse model and investigated a possible mechanism underlying the depressive-like state of ovariectomized mice.
methodsWe removed both ovaries of female ICR mice at 9 weeks of age. Changes in the immobility time during the forced swimming test as a function of the time interval between ovariectomy and behavioral testing were determined on nine different days after surgery. To assess behavioral specificity, the elevated plus-maze (EPM) behavior and spontaneous activity were measured. With respect to the effect of ovariectomy on the immobility time, we compared ICR mice with three other strains of mice (C57BL/6J, DBA/2N, and CD-1). Finally, we investigated the effects of (-)-2,5-dimethoxy-4-iodoamphetamine (DOI) and (+/-)-8-hydroxy-2-(N,N-di-n-propylamino) tetralin (8-OH-DPAT) on the immobility time of ovariectomized mice.
resultsA significant effect on the prolongation of immobility was observed between 12 and 18 days after ovariectomy. Ovariectomy did not alter either the EPM behavior or spontaneous activity. Of the four strains of mice, only DBA mice did not show any significant prolongation of immobility after ovariectomy. Acute or chronic treatment with DOI (0.5 or 1.0 mg kg(-1)) significantly prevented the prolongation of immobility time, whereas acute and chronic treatments with 8-OH-DPAT (0.05, 0.5, or 1.0 mg kg(-1)) were ineffective.
conclusionThe present findings have potentially important implications for evaluating a candidate substance for the management of mood disorders in menopausal women.
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