ArticleJournal of bacteriology2006
Characterization of the primary starch utilization operon in the obligate anaerobe Bacteroides fragilis: Regulation by carbon source and oxygen.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.
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Who cites it
95 citing papers in PubMed, 142 citations in OpenAlex.
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- Intersite differences in gut microbiome are associated with habitat quality in a limestone forest-dwelling langur.BMC microbiology · 2026Article
- Effects of cotton straw and apple pomace mixed ensilage on growth performance, slaughter performance, meat quality, rumen microbiota and metabolome of Xinjiang Brown cattle.Frontiers in veterinary science · 2026Article
- Maternal Taishan Panshi San supplementation is associated with improved foal growth performance, accompanied by alterations in gut microbiota and metabolic profiles.Frontiers in microbiology · 2026Article
- Gene regulation inMicrobiology and molecular biology reviews : MMBR · 2025Review
- Evaluation of feeding effects of pelletized total mixed ration in Hu sheep: growth performance, bacterial community and rumen fermentation.Animal bioscience · 2025Article
- Effects of Fermentation and Enzymatic Hydrolysis of Cottonseed Protein on Rumen Fermentation Characteristics, Intestinal Barrier Function, and Hepatic Metabolism in Suckling Lambs.Animals : an open access journal from MDPI · 2025Article
- Traditional Chinese herbal formulas modulate inflammatory mediators, antioxidant enzyme levels, and ruminal microbiota composition in postpartum female Yaks.Scientific reports · 2025Article
- Dietary Galacto-Oligosaccharides Enhance Growth Performance and Modulate Gut Microbiota in Weaned Piglets: A Sustainable Alternative to Antibiotics.Animals : an open access journal from MDPI · 2025Article
- Variations in Intestinal Microbiota Among Three Species in the Cervidae Family Under the Same Feeding Conditions.Veterinary sciences · 2025Article
- Article
- Effects of different fiber levels of energy feeds on rumen fermentation and the microbial community structure of grazing sheep.BMC microbiology · 2025Article
- Gut microbiome reveals the trophic variation and significant adaption of three sympatric forest-dwelling ungulates on the eastern Qinghai-Xizang Plateau.BMC microbiology · 2025Article
- Culture-Independent Species-Level Taxonomic and Functional Characterisation of Bacteroides, the Core Bacterial Genus Within Reptile Guts.Molecular ecology · 2025Article
- Evaluating the Effect of Dietary Protein-Energy Ratios on Yak Intestinal Microbiota Using High-Throughput 16S rRNA Gene Sequencing.Veterinary sciences · 2025Article
- Ecological and Functional Changes in the Hindgut Microbiome of Holstein Cows at High Altitudes.Animals : an open access journal from MDPI · 2025Article
- Rumen Bacterial Community Responses to Three DHA Supplements: A Comparative In Vitro Study.Animals : an open access journal from MDPI · 2025Article
- Characterization and comparison of the fecal bacterial microbiota in Red Back Pine Root Snake (Frontiers in microbiology · 2025Article
35 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The opportunistic pathogen Bacteroides fragilis is a commensal organism in the large intestine, where it utilizes both dietary and host-derived polysaccharides as a source of carbon and energy. In this study, a four-gene operon required for starch utilization was identified. The operon also was found to be oxygen responsive and thus was designated osu for oxygen-induced starch utilization. The first three genes in the operon were predicted to encode outer membrane proteins involved in starch binding, and a fourth gene, osuD, encoded an amylase involved in starch hydrolysis. Insertional mutation of the osuA gene (Omega osuA) resulted in the inability to utilize starch or glycogen and an insertional mutation into the osuD gene (Omega osuD) was severely impaired for growth on starch media. Transcriptional studies indicated that maltose, maltooligosaccharides, and starch were inducers of osu expression and that maltose was the strongest inducer. A transcriptional activator of osuABCD, OsuR, was identified and found to mediate maltose induction. The Omega osuA and Omega osuD mutants were able to grow on maltose but not starch, whereas a mutation in osuR abolished growth on both substrates, indicating that additional genes under the control of OsuR are needed for maltose utilization. The osuABCD operon also was induced by exposure to oxygen and was shown to be part of the oxidative stress response important for aerotolerance of B. fragilis. Transcriptional analyses showed that osuA was induced 20-fold by oxygen, but OsuR was not required for this activation. Analysis of osu mutants suggested that expression of the operon was important for survival during oxygen exposure but not to hydrogen peroxide stress.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.