Evidence map›Paper›PMID 16787664›Full record

ReviewNeurotoxicology2006

Maternal infection and white matter toxicity.

G Jean Harry, Cindy Lawler, Susan H Brunssen

Open access · greenAbstract readReview
In one paragraph

Review in Neurotoxicology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Neuropathological Consequences of Gestational Exposure to Concentrated Ambient Fine and Ultrafine Particles in the Mouse.Toxicological sciences : an official journal of the Society of Toxicology · 2017
    Article
  5. Article
  6. Review
  7. Article
  8. Maternal immune activation alters fetal brain development through interleukin-6.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

G Jean HarryNeurotoxicology Group, Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health/DHHS, Research Triangle Park, NC 27709, USA. harry@niehs.nih.gov
Cindy Lawler
Susan H Brunssen
National Institutes of Health · US

Funding

Environmentally Induced Alterations In Neuron And Glia Development and AgingZIAES021164 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI HARRY, GAYLIA JEAN · 2009 to 2021
$15.4M
Neuroimmunotoxicology: autoimmunity, viral, infectious aZ01ES101623 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI HARRY, GAYLIA JEAN · 2003 to 2008
$2.8M
Neuroimmunotoxicology: autoimmunity, inflammation, age, environmental agentsZIAES101623 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI HARRY, GAYLIA JEAN · 2009 to 2012
$1.7M
Environment Effects and Development of Neuron and GliaZ01ES021164 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI HARRY, GAYLIA JEAN · 1997 to 2008
$409k
NIEHS NIH HHS Z01 ES021164-09
6 · The paper itself

Abstract

Studies examining maternal infection as a risk factor for neurological disorders in the offspring have suggested that altered maternal immune status during pregnancy can be considered as an adverse event in prenatal development. Infection occurring in the mother during the gestational period has been implicated in multiple neurological effects. The current manuscript will consider the issue of immune/inflammatory conditions during prenatal development where adverse outcomes have been linked to maternal systemic infection. The discussions will focus primary on white matter and oligodendrocytes as they have been identified as target processes. This white matter damage occurs in very early preterm infants and in various other human diseases currently being examined for a linkage to maternal or early developmental immune status. The intent is to draw attention to the impact of altered immune status during pregnancy on the offspring for the consideration of such contributing factors to the general assessment of developmental neurotoxicology.

Indexed as

Disease SusceptibilityAnimalsBrainDisease Models, AnimalFemaleHumansNervous System DiseasesPregnancyPregnancy Complications, Infectious

Identifiers

PMID16787664
PMCPMC1592133
OpenAlexW2023391562

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.