ArticleAtherosclerosis2007
High interleukin-6 plasma levels are associated with low HDL-C levels in community-dwelling older adults: the InChianti study.
Article in Atherosclerosis, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
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- Key co-expressed genes correlated with blood serum parameters of pigs fed with different fatty acid profile diets.Frontiers in genetics · 2024Article
- Association between HDL-C and chronic pain: data from the NHANES database 2003-2004.Frontiers in medicine · 2024Article
- Low levels of small HDL particles predict but do not influence risk of sepsis.Critical care (London, England) · 2023Article
- CIGB-258 Exerts Potent Anti-Inflammatory Activity against Carboxymethyllysine-Induced Acute Inflammation in Hyperlipidemic Zebrafish via the Protection of Apolipoprotein A-I.International journal of molecular sciences · 2023Article
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- Triglyceride-to-High-Density Lipoprotein Cholesterol Ratio and Systemic Inflammation in Patients with Idiopathic Pulmonary Arterial Hypertension.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Natural Killer Response and Lipo-Metabolic Profile in Adults with Low HDL-Cholesterol and Mild Hypercholesterolemia: Beneficial Effects of Artichoke Leaf Extract Supplementation.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Metabolic Syndrome and the Risk of Gastrointestinal Cancer: a Case-Control StudyAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Frequency of metabolic syndrome and associated factors in institutionalized elderly individuals.Clinical interventions in aging · 2018Article
- Targeting Tumor Necrosis Factor Alpha for Alzheimer's Disease.Current Alzheimer research · 2017Review
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- The 5A apolipoprotein A-I (apoA-I) mimetic peptide ameliorates experimental colitis by regulating monocyte infiltration.British journal of pharmacology · 2016Article
- Role of Helicobacter pylori and interleukin 6 -174 gene polymorphism in dyslipidemia: a case-control study.BMJ open · 2016Article
- Lipids and lipoproteins and inflammatory markers in patients with chronic apical periodontitis.Lipids in health and disease · 2015Article
- Therapeutic ultrasound: Increased HDL-Cholesterol following infusions of acoustic microspheres and apolipoprotein A-I plasmids.Atherosclerosis · 2015Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundLow levels of high density lipoprotein cholesterol (HDL-C) are associated with increased incidence of coronary heart disease (CHD). A better understanding of the mechanisms leading to low HDL-C and CHD is essential for planning treatment strategies. Clinical studies have demonstrated that cytokines might affect both concentration and composition of plasma lipoproteins, including HDLs.
methodsWe investigated the possible association between low HDL-C levels, defined as < or =10th gender specific percentile, and circulating markers of inflammation (IL-1beta, TNF-alpha, IL-6, IL-10, IL-18, and CRP) in a population of 1044 community dwelling older Italian subjects from the InChianti study.
resultsUsing logistic regression analysis we demonstrated that IL-6 levels (III versus I tertile, OR: 2.10; 1.10-3.75), TG (III versus I tertile OR: 27.45; 8.47-88.93), fasting insulin (III versus I tertile OR: 2.84; 1.50-5.42), and age (OR: 1.038; 1.002-1.075) were associated with low HDL-C independent of smoking, BMI, waist circumference, hypertension, diabetes, physical activity, alcohol intake, oral hypoglycaemics, CRP, IL-18, and TNF-alpha levels. The adjusted attributable risk of low HDL-C in the exposed group (III tertile of IL-6) was 54%.
conclusionsThe present study provides the epidemiological evidence that besides triglycerides, fasting insulin, and age, IL-6 is one of the main correlates of low HDL-C levels in older individuals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.