ArticleHead & face medicine2006
Expression of caspase-3, p53 and Bcl-2 in generalized aggressive periodontitis.
Article in Head & face medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Influence of Smoking on Fibroblast Apoptosis in Patients With Chronic and Aggressive Periodontitis
Hippo Signaling Pathway Proteins and Their Correlation With Markers of Apoptosis and Bone Metabolism in the Gingival Crevicular Fluid of Individuals With Periodontal Disease
Who cites it
16 citing papers in PubMed, 42 citations in OpenAlex.
- Comparison of salivary caspase-3 biomarker in peri-implantitis among type 2 diabetic patients.Bioinformation · 2026Article
- DNA Methylation in Periodontal Disease: A Focus on Folate, Folic Acid, Mitochondria, and Dietary Intervention.International journal of molecular sciences · 2025Review
- P53 Alleviates the Progression of Periodontitis by Reducing M1-type Macrophage Differentiation.Inflammation · 2024Article
- Mitochondria: An Emerging Unavoidable Link in the Pathogenesis of Periodontitis Caused byInternational journal of molecular sciences · 2024Review
- Evaluation of P53 protein expression in gingival tissues of patients with chronic periodontitis by immunohistochemistry methods.Clinical and experimental dental research · 2022Article
- Protective Effect of Pycnogenol against Methotrexate-Induced Hepatic, Renal, and Cardiac Toxicity: An In Vivo Study.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Article
- Senescent cells exacerbate chronic inflammation and contribute to periodontal disease progression in old mice.Journal of periodontology · 2021Article
- The Photomodulation Activity of Metformin Against Oral Microbiome.Journal of lasers in medical sciences · 2019Review
- Spontaneous PMN apoptosis in type 2 diabetes and the impact of periodontitis.Journal of leukocyte biology · 2017Article
- Regulation of p53 under hypoxic and inflammatory conditions in periodontium.Clinical oral investigations · 2016Article
- S100, bcl2 and myeloperoxid protein expirations during periodontal inflammation.BMC oral health · 2015Article
- In vivo effects of zoledronic acid on oral mucosal epithelial cells.Oral diseases · 2011Article
- Oral malodorous compound activates mitochondrial pathway inducing apoptosis in human gingival fibroblasts.Clinical oral investigations · 2010Article
- WY-14643, a Potent Peroxisome Proliferator Activator Receptor-α PPAR-α Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis.PPAR research · 2010Article
- Effects of etanercept, a tumour necrosis factor-alpha antagonist, in an experimental model of periodontitis in rats.British journal of pharmacology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundApoptosis, or programmed cell death is a form of physiological cell death. It is increased or decreased in the presence of infection, inflammation or tissue remodelling. Previous studies suggest that apoptosis is involved in the pathogenesis of inflammatory periodontal disease. The aim of the present study was to investigate the clinical features and known indicators of apoptosis (p53, Bcl-2, Caspase-3) in patients with generalized aggressive periodontitis (GAP)
methodsEight patients with GAP, who had sites with probing depths (PD) > 5 mm, and 10 periodontally-healthy persons were included in the study. Clinical examinations and PD were performed, and the plaque index and gingival index were recorded. Gingival tissues biopsies were obtained from active site of each patient and from healthy individuals. The expression of caspase-3, Bcl-2, and p53 was evaluated by immunohistochemistry
resultsThere were no significant differences between GAP and control group with respect to levels of caspase-3 and p53 expression (P > 0.05). Contrary, the frequency of grade 3 expression of Bcl-2 was higher in GAP group than the control group.
conclusionThe higher frequency of Bcl-2 expression in GAP group indicates and delayed apoptosis can lead to increasing resident inflammatory cells in periodontal tissues and resulting in progressive periodontal destruction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.