ArticleThe Biochemical journal2006
Regulation of GLUT4 gene expression by SREBP-1c in adipocytes.
Article in The Biochemical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 65 citations in OpenAlex.
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- The Functional Interaction Between PRDM16 and the SREBP Pathway Controls Lipid Metabolism.International journal of molecular sciences · 2025Article
- Antihyperglycemic activity of 14-deoxy, 11, 12-didehydro andrographolide on streptozotocin-nicotinamide induced type 2 diabetic rats.Molecular biology reports · 2023Article
- Fatty Acid Induced Hypermethylation in theInternational journal of molecular sciences · 2023Article
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- Propionic acid counteracts the inflammation of human subcutaneous adipose tissue: a new avenue for drug development.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2019Article
- 1α, 25-dihydroxy Vitamin D3 containing fractions of Catharanthus roseus leaf aqueous extract inhibit preadipocyte differentiation and induce lipolysis in 3T3-L1 cells.BMC complementary and alternative medicine · 2019Article
- A Journey to Understand Glucose Homeostasis: Starting from Rat Glucose Transporter Type 2 Promoter Cloning to Hyperglycemia.Diabetes & metabolism journal · 2018Review
- Erythritol reduces small intestinal glucose absorption, increases muscle glucose uptake, improves glucose metabolic enzymes activities and increases expression of Glut-4 and IRS-1 in type 2 diabetic rats.European journal of nutrition · 2018Article
- Estrogen Receptor 1 (ESR1) EnhancesInternational journal of medical sciences · 2018Article
- Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling.Journal of lipid research · 2013Article
- Exercise training enhances white adipose tissue metabolism in rats selectively bred for low- or high-endurance running capacity.American journal of physiology. Endocrinology and metabolism · 2013Article
- Insulin signalling mechanisms for triacylglycerol storage.Diabetologia · 2013Review
- Insulin signaling in type 2 diabetes: experimental and modeling analyses reveal mechanisms of insulin resistance in human adipocytes.The Journal of biological chemistry · 2013Article
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- Mechanisms of chronic state of inflammation as mediators that link obese adipose tissue and metabolic syndrome.Mediators of inflammation · 2013Review
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- Chronic inhibition of the mTORC1/S6K1 pathway increases insulin-induced PI3K activity but inhibits Akt2 and glucose transport stimulation in 3T3-L1 adipocytes.Molecular endocrinology (Baltimore, Md.) · 2010Article
- Metabolic phenotyping of a model of adipocyte differentiation.Physiological genomics · 2009Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Expression of the GLUT4 (glucose transporter type 4 isoform) gene in adipocytes is subject to hormonal or metabolic control. In the present study, we have characterized an adipose tissue transcription factor that is influenced by fasting/refeeding regimens and insulin. Northern blotting showed that refeeding increased GLUT4 mRNA levels for 24 h in adipose tissue. Consistent with an increased GLUT4 gene expression, the mRNA levels of SREBP (sterol-regulatory-element-binding protein)-1c in adipose tissue were also increased by refeeding. In streptozotocin-induced diabetic rats, insulin treatment increased the mRNA levels of GLUT4 in adipose tissue. Serial deletion, luciferase reporter assays and electrophoretic mobility-shift assay studies indicated that the putative sterol response element is located in the region between bases -109 and -100 of the human GLUT4 promoter. Transduction of the SREBP-1c dominant negative form to differentiated 3T3-L1 adipocytes caused a reduction in the mRNA levels of GLUT4, suggesting that SREBP-1c mediates the transcription of GLUT4. In vivo chromatin immunoprecipitation revealed that refeeding increased the binding of SREBP-1 to the putative sterol-response element in the GLUT4. Furthermore, treating streptozotocin-induced diabetic rats with insulin restored SREBP-1 binding. In addition, we have identified an Sp1 binding site adjacent to the functional sterol-response element in the GLUT4 promoter. The Sp1 site appears to play an additive role in SREBP-1c mediated GLUT4 gene upregulation. These results suggest that upregulation of GLUT4 gene transcription might be directly mediated by SREBP-1c in adipose tissue.
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