ArticleJournal of cancer research and clinical oncology2006
The membrane-cytoskeleton organizer ezrin is necessary for hepatocellular carcinoma cell growth and invasiveness.
Article in Journal of cancer research and clinical oncology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 47 citations in OpenAlex.
- Concanavalin A inhibits human liver cancer cell migration by regulating F-actin redistribution and assembly via MAPK signaling pathway.Oncology letters · 2022Article
- ELIMINATOR: essentiality analysis using multisystem networks and integer programming.BMC bioinformatics · 2022Article
- Review
- Ezrin contributes to cervical cancer progression through induction of epithelial-mesenchymal transition.Oncotarget · 2016Article
- CD147 promotes Src-dependent activation of Rac1 signaling through STAT3/DOCK8 during the motility of hepatocellular carcinoma cells.Oncotarget · 2015Article
- Co-Expression of Ezrin-CLIC5-Podocalyxin Is Associated with Migration and Invasiveness in Hepatocellular Carcinoma.PloS one · 2015Article
- Dinitrosopiperazine-mediated phosphorylated-proteins are involved in nasopharyngeal carcinoma metastasis.International journal of molecular sciences · 2014Article
- Oridonin induces the apoptosis of metastatic hepatocellular carcinoma cells via a mitochondrial pathway.Oncology letters · 2013Article
- Silence of ezrin modifies migration and actin cytoskeleton rearrangements and enhances chemosensitivity of lung cancer cells in vitro.Molecular and cellular biochemistry · 2013Article
- Mechanisms underlying cancer progression caused by ezrin overexpression in tongue squamous cell carcinoma.PloS one · 2013Article
- Cytoplasmic ezrin and moesin correlate with poor survival in head and neck squamous cell carcinoma.Head and neck pathology · 2012Article
- Expression and significance of Six1 and Ezrin in cervical cancer tissue.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2011Article
- Expression change of ezrin as a prognostic factor in primary osteosarcoma.Medical oncology (Northwood, London, England) · 2011Article
- Expression of ezrin in human embryonic, fetal, and normal adult tissues.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2011Article
- N,N'-dinitrosopiperazine-mediated ezrin protein phosphorylation via activation of Rho kinase and protein kinase C is involved in metastasis of nasopharyngeal carcinoma 6-10B cells.The Journal of biological chemistry · 2011Article
- Proteomic analysis of differentially expressed proteins in peripheral cholangiocarcinoma.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2010Article
- Berberine inhibits metastasis of nasopharyngeal carcinoma 5-8F cells by targeting Rho kinase-mediated Ezrin phosphorylation at threonine 567.The Journal of biological chemistry · 2009Article
- Phosphorylated ezrin is associated with EBV latent membrane protein 1 in nasopharyngeal carcinoma and induces cell migration.Oncogene · 2009Article
- Sp1 and AP-1 regulate expression of the human gene VIL2 in esophageal carcinoma cells.The Journal of biological chemistry · 2009Article
- Knockdown of Ezrin inhibited migration and invasion of cervical cancer cells in vitro.International journal of immunopathology and pharmacologyArticle
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe change of cell mobility is one of the preconditions of tumor metastasis. Cell skeleton alteration and rearrangement of F-actin was closely related to cell mobility. Ezrin is a membrane-cytoskeleton organizer that can mediate the rearrangement and the function of F-actin. In this paper, we investigated the effect of ezrin on hepatocellular carcinoma cell growth and invasiveness.
methodsHepatocellular carcinoma cell lines such as MHCC-1, MHCC97-H, SF7721, SMMC7721, Hep3B, and HepG2 were chosen in this study. We first examined the expression and the distribution of ezrin and F-actin in these cell lines using immunofluorescence, RT-PCR, and the western blot. Next we used small interfering RNA (siRNA) to down-regulate ezrin expression in MHCC-1, MHCC97-H, SF7721, and HepG2 to investigate the role of ezrin in tumor cell growth and invasiveness.
resultsOur preliminary results showed that the expression of ezrin and gamma-actin in MHCC-1, MHCC97-H, and SF7721 with higher metastatic potential were obviously up-regulated than those in SMMC7721, Hep3B, and HepG2 with lower potential. No different expression of beta-actin was found in the above tumor cell lines. The outcome of RNAi indicated that decreasing ezrin expression can notably inhibit the proliferation of the four hepatocellular carcinoma cell lines (p < 0.01, n = 10). The proportion of cells in G2-M phase also decreased after RNAi. The number of pseudopods decreased as well after RNAi treatment (p < 0.01, n = 5). The mobility and invasiveness of cancer cells decreased with decreasing ezrin expression tested by transwell assay (p < 0.01, n = 8).
conclusionEzrin plays an important role in the process of hepatocellular carcinoma cell proliferation, migration, and invasiveness.
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