Trial reportEuropean journal of applied physiology2006
Living high-training low: effect on erythropoiesis and maximal aerobic performance in elite Nordic skiers.
Trial report in European journal of applied physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The Effects of Intermittent Hypoxic Training Strategies on Maximal Oxygen Uptake in Healthy Humans: A Meta-analysis with Meta-regression.Sports medicine (Auckland, N.Z.) · 2026Pooled it
- The relationship between hemoglobin andPloS one · 2023Pooled it
- Sea-level exercise performance following adaptation to hypoxia: a meta-analysis.Sports medicine (Auckland, N.Z.) · 2009Pooled it
- Adding heat to the live-high train-low altitude model: a practical insight from professional football.British journal of sports medicine · 2013Trial
- Effects of acute hypoxia tests on blood markers in high-level endurance athletes.European journal of applied physiology · 2009Trial
- Hematological, inflammatory, and hypoxia-responsive adaptations to 18-day normobaric live high-train low training in elite rowers.Frontiers in physiology · 2026Article
- Sleep at high altitude: A bibliometric study and visualization analysis from 1992 to 2022.Heliyon · 2024Article
- Physiological and performance effects of live high train low altitude training for elite endurance athletes: A narrative review.Current research in physiology · 2023Review
- Hepcidin and erythroferrone response to 3 weeks of exposure to normobaric hypoxia at rest in trained cyclists.Frontiers in physiology · 2023Article
- Monitoring Physiological Performance over 4 Weeks Moderate Altitude Training in Elite Chinese Cross-Country Skiers: An Observational Study.International journal of environmental research and public health · 2022Observational
- The Effect of Normobaric Hypoxia in Middle- and/or Long-Distance Runners: Systematic Review.Biology · 2022Review
- The Effects of Altitude Training on Erythropoietic Response and Hematological Variables in Adult Athletes: A Narrative Review.Frontiers in physiology · 2018Review
- Autophagy Is a Promoter for Aerobic Exercise Performance during High Altitude Training.Oxidative medicine and cellular longevity · 2018Review
- Impact of extreme exercise at high altitude on oxidative stress in humans.The Journal of physiology · 2016Review
- Same Performance Changes after Live High-Train Low in Normobaric vs. Hypobaric Hypoxia.Frontiers in physiology · 2016Article
- Increased Hypoxic Dose After Training at Low Altitude with 9h Per Night at 3000m Normobaric Hypoxia.Journal of sports science & medicine · 2015Article
- Alterations in redox homeostasis in the elite endurance athlete.Sports medicine (Auckland, N.Z.) · 2015Article
- The carbon monoxide re-breathing method can underestimate Hbmass due to incomplete blood mixing.European journal of applied physiology · 2013Article
- Hypoxic conditions and exercise-to-rest ratio are likely paramount.Sports medicine (Auckland, N.Z.) · 2012Article
- Living at high altitude in combination with sea-level sprint training increases hematological parameters but does not improve performance in rats.European journal of applied physiology · 2011Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The "living high-training low" model (Hi-Lo) may improve aerobic performance in athletes, and the main mechanism of this improvement is thought to be augmented erythropoiesis. A positive effect of Hi-Lo has been demonstrated previously by using altitudes of 2,000-3,000 m. Since the rate of erythropoiesis is altitude-dependent, we tested whether a higher altitude (3,500 m) during Hi-Lo increases erythropoiesis and maximal aerobic performance. Nordic skiers trained for 18 days at 1,200 m, while sleeping at 1,200 m in ambient air (control group, n = 5) or in hypoxic rooms (Hi-Lo, n = 6; 3 x 6 days at simulated altitudes of 2,500, 3,000 and finally 3,500 m, 11 h day(-1)). Measurements were done before, during (blood samples only) and 2 weeks after the intervention (POST). Maximal aerobic performance was examined from VO(2max) and time to exhaustion (T(exh)) at vVO(2max) (minimum speed associated with VO(2max)), respectively. Erythropoietin and soluble transferrin receptor responses were higher during Hi-Lo, whereas reticulocytes did not change. In POST (vs. before): hematological parameters were similar to basal levels, as well as red blood cell volume, being 2.68 +/- 0.83 l (vs. 2.64+/-0.54 l) in Hi-Lo and 2.62+/-0.57 l (vs. 2.87 +/- 0.59 l) in controls. At that time, neither VO(2max) nor T(exh) were improved by Hi-Lo, VO(2max) being non-significantly decreased by 2.0% (controls) and 3.7% (Hi-Lo). The present results suggest that increasing the altitude up to 3,500 m during Hi-Lo stimulates erythropoiesis but does not confer any advantage for maximal O2 transport.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.