ArticlePlant molecular biology2006
AtRLI2 is an endogenous suppressor of RNA silencing.
Article in Plant molecular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 49 citations in OpenAlex.
- Targeting ParPMC Susceptibility Hubs in Prunus: eEF1A as a Conserved Mediator of Plum Pox Virus Infection in Nicotiana benthamiana.Molecular plant pathology · 2026Article
- The Molecular Cochaperone NbSGT1 May Function as an Endogenous Suppressor of RNA Silencing That Is Recruited by a Potyvirus in Infection of Plants.Molecular plant pathology · 2026Article
- Phylogenetic insight into ABCE gene subfamily in plants.Frontiers in genetics · 2024Article
- Identification and Characterization of ATP-Binding Cassette Transporters inMarine drugs · 2022Article
- Article
- The Arabidopsis ATP-Binding Cassette E protein ABCE2 is a conserved component of the translation machinery.Frontiers in plant science · 2022Article
- Genome-wide analysis of ATP-binding cassette transporter provides insight to genes related to bioactive metabolite transportation in Salvia miltiorrhiza.BMC genomics · 2021Article
- Mutational analysis of Arabidopsis thaliana ABCE2 identifies important motifs for its RNA silencing suppressor function.Plant biology (Stuttgart, Germany) · 2021Article
- ABCE Proteins: From Molecules to Development.Frontiers in plant science · 2018Review
- Article
- Diversity of ABC transporter genes across the plant kingdom and their potential utility in biotechnology.BMC biotechnology · 2016Article
- Interplays between Soil-Borne Plant Viruses and RNA Silencing-Mediated Antiviral Defense in Roots.Frontiers in microbiology · 2016Review
- Genetic variability and evolutionary diversification of membrane ABC transporters in plants.BMC plant biology · 2015Article
- ABCE1 is a highly conserved RNA silencing suppressor.PloS one · 2015Article
- Comparative analysis of ABCB1 reveals novel structural and functional conservation between monocots and dicots.Frontiers in plant science · 2014Article
- Whole-genome survey of the putative ATP-binding cassette transporter family genes in Vitis vinifera.PloS one · 2013Article
- Arabidopsis FIERY1, XRN2, and XRN3 are endogenous RNA silencing suppressors.The Plant cell · 2007Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA silencing is a mechanism involved in gene regulation during development and anti-viral defense in plants and animals. Although many viral suppressors of this mechanism have been described up to now, this is not the case for endogenous suppressors. We have identified a novel endogenous suppressor in plants: RNase L inhibitor (RLI) of Arabidopsis thaliana. RLI is a very conserved protein among eukaryotes and archaea. It was first known as component of the interferon-induced mammalian 2'-5' oligoadenylate (2-5A) anti-viral pathway. This protein is in several organisms responsible for essential functions, which are not related to the 2-5A pathway, like ribosome biogenesis and translation initiation. Arabidopsis has two RLI paralogs. We have described in detail the expression pattern of one of these paralogs (AtRLI2), which is ubiquitously expressed in all plant organs during different developmental stages. Infiltrating Nicotiana benthamiana green fluorescent protein (GFP)-transgenic line with Agrobacterium strains harboring GFP and AtRLI2, we proved that AtRLI2 suppresses silencing at the local and at the systemic level, reducing drastically the amount of GFP small interfering RNAs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.