ArticleEndocrine2006
Effects of age, gender, and gonadectomy on neurochemistry and behavior in animal models of Parkinson's disease.
Article in Endocrine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Impact of aging on animal models of Parkinson's disease.Frontiers in aging neuroscience · 2022Pooled it
- Accelerometry is a valid method to distinguish between healthy and 6-OHDA-lesioned parkinsonian rats.Scientific reports · 2025Article
- Sex and gender differences in the molecular etiology of Parkinson's disease: considerations for study design and data analysis.Biology of sex differences · 2025Review
- [Androgens and Parkinson's disease: the role in humans and in experiment].Problemy endokrinologii · 2022Review
- Alterations of Nigral Dopamine Levels in Parkinson's Disease after Environmental Enrichment and PACAP Treatment in Aging Rats.Life (Basel, Switzerland) · 2021Article
- Androgens and Parkinson's Disease: A Review of Human Studies and Animal Models.Androgens: clinical research and therapeutics · 2021Review
- Impact of Aging on the 6-OHDA-Induced Rat Model of Parkinson's Disease.International journal of molecular sciences · 2020Article
- PACAP deficiency as a model of aging.GeroScience · 2018Review
- Exacerbation of sensorimotor dysfunction in mice deficient in Atp13a2 and overexpressing human wildtype alpha-synuclein.Behavioural brain research · 2018Article
- Effects of Postnatal Enriched Environment in a Model of Parkinson's Disease in Adult Rats.International journal of molecular sciences · 2017Article
- Pituitary adenylate cyclase-activating polypeptide (PACAP) has a neuroprotective function in dopamine-based neurodegeneration in rat and snail parkinsonian models.Disease models & mechanisms · 2017Article
- Gender-dependent effects of enriched environment and social isolation in ischemic retinal lesion in adult rats.International journal of molecular sciences · 2013Article
- Castration induces Parkinson disease pathologies in young male mice via inducible nitric-oxide synthase.The Journal of biological chemistry · 2013Article
- Reproductive capability is associated with lifespan and cause of death in companion dogs.PloS one · 2013Article
- Young and middle-aged rats exhibit isometric forelimb force control deficits in a model of early-stage Parkinson's disease.Behavioural brain research · 2011Article
- Androgens exacerbate motor asymmetry in male rats with unilateral 6-hydroxydopamine lesion.Hormones and behavior · 2011Article
- Sex differences in motor behavior in the MPTP mouse model of Parkinson's disease.Pharmacology, biochemistry, and behavior · 2010Article
- Reproductive factors, exogenous estrogen use, and risk of Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society · 2009Article
- Sex differences in skilled movement in response to restraint stress and recovery from stress.Behavioural brain research · 2008Article
- Changes in the content of estrogen alpha and progesterone receptors during differentiation of mouse embryonic stem cells to dopamine neurons.Brain research bulletin · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of aging and gender on the neurochemistry of the dopaminergic system have been studied extensively; however, data on comparative behavioral consequences of lesions of the dopaminergic system in aging and in female animals are limited. This study presents experimental results on the behavioral and morphological outcome in young, aging, and gonadectomized male and female rats in the 6-OHDA model of Parkinson's disease. Both young and aging male animals were more susceptible to 6-OHDA than females: female rats had significantly less dopaminergic cell loss and showed a higher degree of behavioral recovery. Although the dopaminergic cell loss was only slightly more in the aging rats of the same sex, they showed more severe behavioral deficits in both gender groups. Ovariectomy did not significantly influence the dopaminergic cell loss, but behavioral recovery was worse when compared to non-ovariectomized females. In contrast, castrated males had significantly less dopaminergic cell loss than non-castrated males, but the behavioral recovery was not significantly better. The obtained results are discussed in light of the available literature on the age and gender differences in animals models of Parkinson's disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.