ReviewEndocrine2006
Gender differences in neurological disease: role of estrogens and cytokines.
Review in Endocrine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.
- Mechanisms of estrogens' dose-dependent neuroprotective and neurodamaging effects in experimental models of cerebral ischemia.International journal of molecular sciences · 2011Pooled it
- Clinical Utility of Circulating Biomarkers for Diagnosis and Prognosis of Acute Stroke in the Emergency Department: A Narrative Review from Current Evidence to Clinical Implementation.Diagnostics (Basel, Switzerland) · 2026Review
- Sex-dependent impact ofGenes & diseases · 2026Article
- Hospitalisations related to nervous-system diseases in Australia, 1998-2019: a secular trend analysis.BMJ open · 2023Article
- Association of women-specific health factors in the severity of Parkinson's disease.NPJ Parkinson's disease · 2023Article
- Tissue-Specific Sex Difference in Mouse Eye and Brain Metabolome Under Fed and Fasted States.Investigative ophthalmology & visual science · 2023Article
- Precision Medicine in Glaucoma: Artificial Intelligence, Biomarkers, Genetics and Redox State.International journal of molecular sciences · 2023Review
- Role of gender and age in features of Wilson's disease.Frontiers in neurology · 2023Article
- Impact of sex and APOE-Frontiers in neurology · 2023Article
- Estrogen Up-Regulates Iron Transporters and Iron Storage Protein Through Hypoxia Inducible Factor 1 Alpha Activation Mediated by Estrogen Receptor β and G Protein Estrogen Receptor in BV2 Microglia Cells.Neurochemical research · 2022Article
- Enhanced Cortical Metabolic Activity in Females and Males of a Slow Progressing Mouse Model of Amyotrophic Lateral Sclerosis.Neurochemical research · 2022Article
- Development of an age-adjusted model for blood neurofilament light chain.Annals of clinical and translational neurology · 2022Article
- Sex steroid hormone function in the brain niche: Implications for brain metastatic colonization and progression.Cancer reports (Hoboken, N.J.) · 2022Review
- Sex Hormones and Their Effects on Ocular Disorders and Pathophysiology: Current Aspects and Our Experience.International journal of molecular sciences · 2022Review
- Diagnosis and management of cerebral venous sinus thrombosis in children: a single-center retrospective analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Sex-Specific Effects of Early Life Stress on Brain Mitochondrial Function, Monoamine Levels and Neuroinflammation.Brain sciences · 2020Article
- Central aromatization: A dramatic and responsive defense against threat and trauma to the vertebrate brain.Frontiers in neuroendocrinology · 2020Review
- Arterial ischemic stroke in infants, children, and adolescents: results of a Germany-wide surveillance study 2015-2017.Journal of neurology · 2019Article
- Sex Hormones and Optic Nerve Disorders: A Review.Frontiers in neuroscience · 2019Review
- Modeling Environmentally-Induced Motor Neuron Degeneration in Zebrafish.Scientific reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing evidence suggests that inflammatory response may be a critical component of different brain pathologies. However, the role played by this reaction is not fully understood. The present findings suggest that neuroinflammtory mediators such as cytokines may be involved in a number of key steps in the pathological cascade of events leading to neuronal injury. This hypothesis is strongly supported by experimental and clinical observations indicating that inhibition of the inflammatory reaction correlates with less neuronal damage. Estrogens are thought to play a role in the sex difference observed in many neurological diseases with inflammatory components including stroke, Alzheimer's and Parkinson's diseases, multiple sclerosis, or amyotrophic lateral sclerosis. Clinical and experimental studies have established estrogen as a neuroprotective hormone in these diseases. However, the exact mechanisms involved in the neuroprotective effects of estrogens are still unclear. It is possible that the beneficial effects of these hormones may be dependent on their inhibitory activity on the inflammatory reaction associated with the above-mentioned brain pathologies. Here, we review the current clinical and experimental evidence with respect to the inflammation-modulating effects of estrogens as one potential explanatory factor for sexual dimorzphism in the prevalence of numerous neurological diseases.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.