ReviewEndocrine2006
Multiple pathways transmit neuroprotective effects of gonadal steroids.
Review in Endocrine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 94 citations in OpenAlex.
- Sexual Dimorphism in Levodopa-Induced Dyskinesia Following Parkinson's Disease: Uncharted Territory.The European journal of neuroscience · 2025Review
- Sex, Genes, and Traumatic Brain Injury (TBI): A Call for a Gender Inclusive Approach to the Study of TBI in the Lab.Frontiers in neuroscience · 2021Article
- Sex as a Biological Variable in Preclinical Modeling of Blast-Related Traumatic Brain Injury.Frontiers in neurology · 2020Review
- The Critical Period for Neuroprotection by Estrogen Replacement Therapy and the Potential Underlying Mechanisms.Current neuropharmacology · 2020Review
- Central aromatization: A dramatic and responsive defense against threat and trauma to the vertebrate brain.Frontiers in neuroendocrinology · 2020Review
- Single dose of 17β-estradiol provides transient neuroprotection in female juvenile mice after cardiac-arrest and cardiopulmonary resuscitation.Neurochemistry international · 2019Article
- Estrogen Interactions With Lipid Rafts Related to Neuroprotection. Impact of Brain Ageing and Menopause.Frontiers in neuroscience · 2018Review
- Sex differences in the psychopharmacological treatment of depression.Dialogues in clinical neuroscience · 2016Review
- Effect of low doses of progesterone in the expression of the GABA(A) receptor α4 subunit and procaspase-3 in the hypothalamus of female rats.Endocrine · 2014Article
- The sex-specific associations of the aromatase gene with Alzheimer's disease and its interaction with IL10 in the Epistasis Project.European journal of human genetics : EJHG · 2014Article
- Recent evidence for rapid synthesis and action of oestrogens during auditory processing in a songbird.Journal of neuroendocrinology · 2013Review
- Brain-derived neurotrophic factor-estrogen interactions in the hippocampal mossy fiber pathway: implications for normal brain function and disease.Neuroscience · 2013Review
- Autobiographical memory, self, and stress-related psychiatric disorders: which implications in cancer patients?Neuropsychology review · 2013Review
- Effect of endocrine therapy on quality of life and cognitive functions in patients with breast cancer.Breast care (Basel, Switzerland) · 2013Article
- Traumatized and inflamed--but resilient: glial aromatization and the avian brain.Hormones and behavior · 2013Review
- Brain estrogen signaling effects acute modulation of acoustic communication behaviors: A working hypothesis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2012Article
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- Neuroprotective actions of estradiol and novel estrogen analogs in ischemia: translational implications.Frontiers in neuroendocrinology · 2011Review
- Rapid action of estradiol in primate GnRH neurons: the role of estrogen receptor alpha and estrogen receptor beta.Steroids · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous preclinical studies suggest that gonadal steroids, particularly estrogen, may be neuroprotective against insult or disease progression. This paper reviews the mechanisms contributing to estrogen-mediated neuroprotection. Rapid signaling pathways, such as MAPK, PI3K, Akt, and PKC, are required for estrogen's ability to provide neuroprotection. These rapid signaling pathways converge on genomic pathways to modulate transcription of E2-responsive genes via ERE-dependent and ERE-independent mechanisms. It is clear that both rapid signaling and transcription are important for estrogen's neuroprotective effects. A mechanistic understanding of estrogen-mediated neuroprotection is crucial for the development of therapeutic interventions that enhance quality of life without deleterious side effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.