ArticleNeurotoxicity research2006
Characterization of Clostridial botulinum neurotoxin channels in neuroblastoma cells.
Article in Neurotoxicity research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Botulinum neurotoxin Light Chain/A1 uses fast synaptic vesicle cycling to cleave plasma membrane bound SNAP-25.Communications biology · 2025Article
- Structural and functional analysis of botulinum neurotoxin subunits for pH-dependent membrane channel formation and translocation.Biochimica et biophysica acta · 2015Article
- Molecular dissection of botulinum neurotoxin reveals interdomain chaperone function.Toxicon : official journal of the International Society on Toxinology · 2013Review
- Assembly and function of the botulinum neurotoxin progenitor complex.Current topics in microbiology and immunology · 2013Review
- Obstructing toxin pathways by targeted pore blockage.Chemical reviews · 2012Review
- Translocation of botulinum neurotoxin light chain protease by the heavy chain protein-conducting channel.Toxicon : official journal of the International Society on Toxinology · 2009Review
- Bimodal modulation of the botulinum neurotoxin protein-conducting channel.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Botulinum neurotoxin devoid of receptor binding domain translocates active protease.PLoS pathogens · 2008Article
- Botulinum neurotoxin: evolution from poison, to research tool--onto medicinal therapeutic and future pharmaceutical panacea.Neurotoxicity research · 2007Review
- Botulinum neurotoxin heavy chain belt as an intramolecular chaperone for the light chain.PLoS pathogens · 2007Article
- Single molecule detection of intermediates during botulinum neurotoxin translocation across membranes.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Lipid and cationic polymer based transduction of botulinum holotoxin, or toxin protease alone, extends the target cell range and improves the efficiency of intoxication.Toxicon : official journal of the International Society on ToxinologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The channel and chaperone activities of Clostridial botulinum neurotoxin (BoNT) A were investigated in Neuro 2a neuroblastoma cells under conditions that closely emulate those prevalent at the endosome. Channel activity occurs in bursts interspersed between periods of little or no activity. The channels are voltage dependent, opening only at negative voltages. Within bursts, the channel resides preferentially in the open state. The channels open to a main conductance of 105 +/- 5 pS or 65 +/- 4 pS in 200 mM CsCl or NaCl, respectively. The BoNT channels display a conspicuous subconductance of 10 +/- 2 pS. The neuroblastoma cell line appears, therefore, to be a suitable system to characterize the BoNT channel and to pursue evaluation of plausible strategies for targeted drug delivery thereby minimizing the requirement for in vivo animal testing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.