ReviewNeurotoxicity research2006
Botulinum neurotoxin structure, engineering, and novel cellular trafficking and targeting.
Review in Neurotoxicity research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Functional Deimmunization of Botulinum Neurotoxin Protease Domain via Computationally Driven Library Design and Ultrahigh-Throughput Screening.ACS synthetic biology · 2023Article
- Therapeutic efficacy of new botulinum toxin identified in CCUG 7968 strain.Applied microbiology and biotechnology · 2021Article
- Clostridial Neurotoxins: Structure, Function and Implications to Other Bacterial Toxins.Microorganisms · 2021Review
- Characterization of immune response induced against catalytic domain of botulinum neurotoxin type E.Scientific reports · 2020Article
- Natural Compounds and Their Analogues as Potent Antidotes against the Most Poisonous Bacterial Toxin.Applied and environmental microbiology · 2018Article
- A Novel Surface Plasmon Resonance Biosensor for the Rapid Detection of Botulinum Neurotoxins.Biosensors · 2017Article
- In Vivo Toxicity and Immunological Characterization of Detoxified Recombinant Botulinum Neurotoxin Type A.Pharmaceutical research · 2016Article
- Structural and functional analysis of botulinum neurotoxin subunits for pH-dependent membrane channel formation and translocation.Biochimica et biophysica acta · 2015Article
- Functional evaluation of biological neurotoxins in networked cultures of stem cell-derived central nervous system neurons.Journal of visualized experiments : JoVE · 2015Article
- Accelerated intoxication of GABAergic synapses by botulinum neurotoxin A disinhibits stem cell-derived neuron networks prior to network silencing.Frontiers in cellular neuroscience · 2015Article
- Molecular composition and extinction coefficient of native botulinum neurotoxin complex produced by Clostridium botulinum hall A strain.The protein journal · 2013Article
- Molecular mechanisms of treadmill therapy on neuromuscular atrophy induced via botulinum toxin A.Neural plasticity · 2013Review
- Alpha7 nicotinic acetylcholine receptor is a target in pharmacology and toxicology.International journal of molecular sciences · 2012Review
- Principles of antidote pharmacology: an update on prophylaxis, post-exposure treatment recommendations and research initiatives for biological agents.British journal of pharmacology · 2010Review
- The case of botulinum toxin in milk: experimental data.Applied and environmental microbiology · 2010Article
- The identification and biochemical characterization of drug-like compounds that inhibit botulinum neurotoxin serotype A endopeptidase activity.Toxicon : official journal of the International Society on Toxinology · 2010Article
- Molecular basis of activation of endopeptidase activity of botulinum neurotoxin type E.Biochemistry · 2010Article
- Thermostable llama single domain antibodies for detection of botulinum A neurotoxin complex.Analytical chemistry · 2008Article
- Botulinum neurotoxin: evolution from poison, to research tool--onto medicinal therapeutic and future pharmaceutical panacea.Neurotoxicity research · 2007Review
- Botulinum neurotoxin light chain refolds at endosomal pH for its translocation.The protein journal · 2006Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Botulinum neurotoxins are multifaceted molecules, which are truly unique not only in their mode of action, but also their utility as a drug carrier either across the gut wall or to the nerve terminals. The molecule is divided in clear functional domains that can operate independently. This feature can be used to employ them as cargo carrier by linking other drugs or vaccines with the binding and translocation domains of BoNT. While the domain structures are largely independent of each other, the dynamic structure of these domains, especially that of the enzymatic domain (L chain), is quite different from the reported crystal structures for several BoNT serotypes and their enzymatic domain. This review discusses the comparative structures of BoNT in crystal and solution for their relevance to the molecular mechanism of BoNT action, especially in view of our recent discovery that the enzymatically active structure of the BoNT exists as a molten-globule and that of the endopeptidase domain as a novel PRIME conformation. Finally, a non-exhaustive discussion has been included to explain the long-lasting biological effects of certain serotypes of BoNT, based on the current knowledge of the structure-function of different serotypes of botulinum neurotoxins.
Indexed as
Identifiers
16785103What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.