ReviewTrends in parasitology2006
Malaria tolerance--for whom the cell tolls?
Review in Trends in parasitology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 76 citations in OpenAlex.
- Exposure-dependent control of malaria-induced inflammation in children.PLoS pathogens · 2014Trial
- The case for exploring innate memory in Plasmodium infection.Current opinion in microbiology · 2026Review
- Recent malaria does not substantially impact COVID-19 antibody response or rates of symptomatic illness in communities with high malaria and COVID-19 transmission in Mali, West Africa.Frontiers in immunology · 2022Article
- Protozoan co-infections and parasite influence on the efficacy of vaccines against bacterial and viral pathogens.Frontiers in microbiology · 2022Review
- The striking mimics between COVID-19 and malaria: A review.Frontiers in immunology · 2022Review
- Review
- Exposure to Diverse Plasmodium falciparum Genotypes Shapes the Risk of Symptomatic Malaria in Incident and Persistent Infections: A Longitudinal Molecular Epidemiologic Study in Kenya.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Immunosuppression in Malaria: DoPathogens (Basel, Switzerland) · 2021Review
- Is malaria immunity a possible protection against severe symptoms and outcomes of COVID-19?Ghana medical journal · 2021Review
- Plasmodium falciparum malaria drives epigenetic reprogramming of human monocytes toward a regulatory phenotype.PLoS pathogens · 2021Article
- What will studies of Fulani individuals naturally exposed to malaria teach us about protective immunity to malaria?Scandinavian journal of immunology · 2020Review
- COVID19 in South Asians/Asian Indians: Heterogeneity of data and implications for pathophysiology and research.Diabetes research and clinical practice · 2020Article
- Article
- Extreme Competence: Keystone Hosts of Infections.Trends in ecology & evolution · 2019Review
- Cutting Edge:Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Epigenetics and Malaria Susceptibility/Protection: A Missing Piece of the Puzzle.Frontiers in immunology · 2018Review
- Surviving Deadly Lung Infections: Innate Host Tolerance Mechanisms in the Pulmonary System.Frontiers in immunology · 2018Review
- Both inflammatory and regulatory cytokine responses to malaria are blunted with increasing age in highly exposed children.Malaria journal · 2017Article
- Patterns of inflammatory responses and parasite tolerance vary with malaria transmission intensity.Malaria journal · 2017Article
- The effect of declining exposure on T cell-mediated immunity to Plasmodium falciparum - an epidemiological "natural experiment".BMC medicine · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
How is it that individuals exposed to intense malaria transmission can tolerate the presence of malaria parasites in their blood at levels that would produce fever in others? In light of evidence discounting a role for nitric oxide or antibodies to plasmodial glycosylphosphatidylinositols in maintaining this tolerant state, refractoriness to toxin-induced Toll-like receptor-mediated signalling has emerged as a likely explanation that links malarial and bacterial endotoxin tolerance. Understanding the mechanisms underlying tolerance and the potential for cross-tolerization has significant implications for understanding the potential for antitoxic vaccine strategies, as well as interactions between different malaria species and between malaria and other human parasites.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.