ArticleMammalian genome : official journal of the International Mammalian Genome Society2006
Candidate genes and their regulatory elements: alcohol preference and tolerance.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis.Proceedings of the National Academy of Sciences of the United States of America · 2006Pooled it
- Identification of novel genetic loci and candidate genes for progressive ethanol consumption in diversity outbred mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Coordination among frequent genetic variants imparts substance use susceptibility and pathogenesis.Frontiers in neuroscience · 2024Article
- Brain injury and inflammation genes common to a number of neurological diseases and the genes involved in the genesis of GABAnergic neurons are altered in monoamine oxidase B knockout mice.Brain research · 2022Article
- Effect of chronic ethanol consumption in rhesus macaques on the nucleus accumbens core transcriptome.Addiction biology · 2021Article
- A Topological Cluster of Differentially Regulated Genes in Mice Lacking PER3.Frontiers in molecular neuroscience · 2020Article
- Tankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on SOX9 PARylation.Nature communications · 2019Article
- Brain Imaging-Guided Analysis Reveals DNA Methylation Profiles Correlated with Insular Surface Area and Alcohol Use Disorder.Alcoholism, clinical and experimental research · 2019Article
- Cross-Species Co-analysis of Prefrontal Cortex Chronic Ethanol Transcriptome Responses in Mice and Monkeys.Frontiers in molecular neuroscience · 2019Article
- On the relationships in rhesus macaques between chronic ethanol consumption and the brain transcriptome.Addiction biology · 2018Article
- Altered gene expression in early postnatal monoamine oxidase A knockout mice.Brain research · 2017Article
- Genetics of gene expression characterizes response to selective breeding for alcohol preference.Genes, brain, and behavior · 2014Article
- Genetics and genomics of alcohol sensitivity.Molecular genetics and genomics : MGG · 2014Review
- Molecular basis of alcoholism.Handbook of clinical neurology · 2014Review
- High-precision genetic mapping of behavioral traits in the diversity outbred mouse population.Genes, brain, and behavior · 2013Article
- FADS2 Genetic Variance in Combination with Fatty Acid Intake Might Alter Composition of the Fatty Acids in Brain.PloS one · 2013Article
- Whole brain and brain regional coexpression network interactions associated with predisposition to alcohol consumption.PloS one · 2013Article
- Gene Expression Under the Influence: Transcriptional Profiling of Ethanol in the Brain.Current psychopharmacology · 2012Article
- Genetic control of a central pattern generator: rhythmic oromotor movement in mice is controlled by a major locus near Atp1a2.PloS one · 2012Article
- Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies.Addiction biology · 2012Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
QTL analysis of behavioral traits and mouse brain gene expression studies were combined to identify candidate genes involved in the traits of alcohol preference and acute functional alcohol tolerance. The systematic application of normalization and statistical analysis of differential gene expression, behavioral and expression QTL location, and informatics methodologies resulted in identification of 8 candidate genes for the trait of alcohol preference and 22 candidate genes for acute functional tolerance. Pathway analysis, combined with clustering by ontology, indicated the importance of transcriptional regulation and DNA and protein binding elements in the acute functional tolerance trait, and protein kinases and intracellular signal transduction elements in the alcohol preference trait. A rudimentary search for transcription control elements that could indicate coregulation of the panels of candidate genes produced modest results, implicating SMAD-3 in the regulation of four of the eight candidate genes for alcohol preference. However, the realization of the many caveats related to transcription factor binding site analysis, and attempts to correlate between transcription factor binding and function, forestalled any definitive global analysis of transcriptional control of differentially expressed candidate genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.