ArticleMammalian genome : official journal of the International Mammalian Genome Society2006
Genetic determinants of weight of fast- and slow-twitch skeletal muscles in old mice.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- The transcription regulator ATF4 is a mediator of skeletal muscle aging.GeroScience · 2023Article
- Sarcopenia: Aging-Related Loss of Muscle Mass and Function.Physiological reviews · 2019 · on this mapReview
- Discovery and refinement of muscle weight QTLs in B6 × D2 advanced intercross mice.Physiological genomics · 2014Article
- Genetic and genomic analyses of musculoskeletal differences between BEH and BEL strains.Physiological genomics · 2013Article
- Isolation, characterization, and molecular regulation of muscle stem cells.Frontiers in physiology · 2013Review
- Resolving candidate genes of mouse skeletal muscle QTL via RNA-Seq and expression network analyses.BMC genomics · 2012Article
- Molecular genetic studies of gene identification for sarcopenia.Human genetics · 2012Review
- Genetic determinants for intramuscular fat content and water-holding capacity in mice selected for high muscle mass.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- Genetic background affects properties of satellite cells and mdx phenotypes.The American journal of pathology · 2010Article
- Bone, muscle, and physical activity: structural equation modeling of relationships and genetic influence with age.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2009Article
- Diverse effects of stanozolol in C57BL/6J and A/J mouse strains.European journal of applied physiology · 2008Article
- Genomic analysis of variation in hindlimb musculature of mice from the C57BL/6J and DBA/2J lineage.The Journal of heredityArticle
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
The main goal of the study was to explore the genetic architecture underlying muscle weight in old mice. Weight of soleus, tibialis anterior (TA), extensor digitorum longus (EDL), and gastrocnemius muscles was measured in the C57BL/6J (B6) and DBA/2J (D2) strains and derivative generations: a panel of the BXD recombinant inbred (RI) strains and a B6D2 F(2) intercross at the age of 800 days. The between-strain difference in muscle weight (B6 > D2) ranged between 16% and 38%. Linkage analysis identified suggestive quantitative trait loci (QTL) on Chromosomes (Chr) 2, 6, 7, 8, 19, and X that influenced muscle weight in the 800-day-old group. Comparison of weights at 200, 500, and 800 days revealed a variable effect of age among the four muscles. Linkage analysis in the B6D2 F(2) population combined across the three different age groups identified muscle-, sex-, and age-specific QTL on Chr 1, 2, 3, 5, 6, 8, 9, 11, 13, 17, X, and Y. Genetic factors that influence the rate of weight change (within-strain weight difference at two ages) over the lifespan of BXD RIs were mapped to the markers D2Mit369 and D3Mit130 at the genome-wide p < 0.05 for TA muscle in males (between 200 and 800 days) and females (between 500 and 800 days), respectively. Analysis of all age groups supported previous findings that the genetic effects may be muscle-, age-, and sex-specific.
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