ArticleMammalian genome : official journal of the International Mammalian Genome Society2006
Gene expression analysis of mouse chromosome substitution strains.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
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- Genetic Influence on Frequencies of Myeloid-Derived Cell Subpopulations in Mouse.Frontiers in immunology · 2021Article
- Genetic Regulation of Guanylate-Binding Proteins 2b and 5 during Leishmaniasis in Mice.Frontiers in immunology · 2018Article
- Gene-specific sex effects on eosinophil infiltration in leishmaniasis.Biology of sex differences · 2016Article
- Genetics of host response to Leishmania tropica in mice - different control of skin pathology, chemokine reaction, and invasion into spleen and liver.PLoS neglected tropical diseases · 2012Article
- Intersubspecific subcongenic mouse strain analysis reveals closely linked QTLs with opposite effects on body weight.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- Genetic control of resistance to Trypanosoma brucei brucei infection in mice.PLoS neglected tropical diseases · 2011Article
- Transcriptome profiling of embryonic development rate in rainbow trout advanced backcross introgression lines.Marine biotechnology (New York, N.Y.) · 2011Article
- The genetics of brown adipocyte induction in white fat depots.Frontiers in endocrinology · 2011Article
- Nocturnin: a circadian target of Pparg-induced adipogenesis.Annals of the New York Academy of Sciences · 2010Article
- Effects of atherogenic diet on hepatic gene expression across mouse strains.Physiological genomics · 2009Article
- Genomic survey of prepulse inhibition in mouse chromosome substitution strains.Genes, brain, and behavior · 2009Article
- Gene expression profiles and breast cancer metastasis: a genetic perspective.Clinical & experimental metastasis · 2009Review
- Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Using gene expression databases for classical trait QTL candidate gene discovery in the BXD recombinant inbred genetic reference population: mouse forebrain weight.BMC genomics · 2008Article
- Mouse inter-subspecific consomic strains for genetic dissection of quantitative complex traits.Genome research · 2008Article
- Mouse consomic strains: exploiting genetic divergence between Mus m. musculus and Mus m. domesticus subspecies.Genome research · 2008Article
- Randomization in laboratory procedure is key to obtaining reproducible microarray results.PloS one · 2008Article
- Interpretation of knockout experiments: the congenic footprint.Genes, brain, and behavior · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
An analysis of transcriptional variation in the liver using a panel of B.A chromosome substitution strains identified 4209 transcripts that are differentially expressed relative to the C57BL/6J background and 1010 transcripts that are differentially expressed between C57BL/6J and A/J strains. A subset of these strains (substituting Chromosomes 1, 6, and 15) was used to identify 386 additional differentially expressed transcripts in the kidney. Approximately 15% of differentially expressed transcripts are located on the substituted chromosome. These cis-QTL are codirectionally expressed with the donor strain A/J. By comparison, trans-regulated loci comprise 85% of differentially expressed transcripts, often show opposite direction of change compared with A/J, and can be regulated by multiple chromosome substitutions. Gene expression differences in this study provide evidence for transgressive segregation: Only 438 of 4209 QTL in liver were inside the parental range. By combining QTL data with known biological functions, we were able to identify physiologic pathways altered in multiple strains. In many cases the same pathways were altered by multiple distinct chromosome substitutions. Taken together, these results suggest that widespread epistatic background effects may result in complex and overlapping transcriptional relationships among different chromosome substitution strains. Transcriptional profiling of chromosome substitution strains reveals a complex genetic architecture of transcriptional regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.