ReviewMammalian genome : official journal of the International Mammalian Genome Society2006
From genetical genomics to systems genetics: potential applications in quantitative genomics and animal breeding.
Review in Mammalian genome : official journal of the International Mammalian Genome Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Integrative multi-omics analysis reveals genetic and heterotic contributions to male fertility and yield in potato.Nature communications · 2024Article
- OMICs approaches and technologies for understanding low-high feed efficiency traits in chicken: implication to breeding.Animal biotechnology · 2023Review
- Harnessing Genomics and Transcriptomics Approaches to Improve Female Fertility in Beef Cattle-A Review.Animals : an open access journal from MDPI · 2023Review
- Genomic Analysis, Progress and Future Perspectives in Dairy Cattle Selection: A Review.Animals : an open access journal from MDPI · 2021Review
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- Article
- Strong impact of thermal environment on the quantitative genetic basis of a key stress tolerance trait.Heredity · 2019Article
- Genetic control of longissimus dorsi muscle gene expression variation and joint analysis with phenotypic quantitative trait loci in pigs.BMC genomics · 2019Article
- Systems genomics study reveals expression quantitative trait loci, regulator genes and pathways associated with boar taint in pigs.PloS one · 2018Article
- Gene Co-expression Analysis Indicates Potential Pathways and Regulators of Beef Tenderness in Nellore Cattle.Frontiers in genetics · 2018Article
- Systems genetics analysis of pharmacogenomics variation during antidepressant treatment.The pharmacogenomics journal · 2018Article
- A genome-wide approach to screen for genetic variants in broilers (Gallus gallus) with divergent feed conversion ratio.Molecular genetics and genomics : MGG · 2016Article
- Multi-omic data integration and analysis using systems genomics approaches: methods and applications in animal production, health and welfare.Genetics, selection, evolution : GSE · 2016Review
- An integrative systems genetics approach reveals potential causal genes and pathways related to obesity.Genome medicine · 2015Article
- Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross.PLoS genetics · 2015Article
- Genome-wide association and systems genetic analyses of residual feed intake, daily feed consumption, backfat and weight gain in pigs.BMC genetics · 2014Article
- Co-expression analysis of fetal weight-related genes in ovine skeletal muscle during mid and late fetal development stages.International journal of biological sciences · 2014Article
- Weighted Interaction SNP Hub (WISH) network method for building genetic networks for complex diseases and traits using whole genome genotype data.BMC systems biology · 2014Article
- Systems genetics of obesity in an F2 pig model by genome-wide association, genetic network, and pathway analyses.Frontiers in genetics · 2014Article
- Genome-wide association and pathway analysis of feed efficiency in pigs reveal candidate genes and pathways for residual feed intake.Frontiers in genetics · 2014Article
Corrections and comments
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
This article reviews methods of integration of transcriptomics (and equally proteomics and metabolomics), genetics, and genomics in the form of systems genetics into existing genome analyses and their potential use in animal breeding and quantitative genomic modeling of complex traits. Genetical genomics or the expression quantitative trait loci (eQTL) mapping method and key findings in this research are reviewed. Various procedures and potential uses of eQTL mapping, global linkage clustering, and systems genetics are illustrated using actual analysis on recombinant inbred lines of mice with data on gene expression (for diabetes- and obesity-related genes), pathway, and single nucleotide polymorphism (SNP) linkage maps. Experimental and bioinformatics difficulties and possible solutions are discussed. The main uses of this systems genetics approach in quantitative genomics were shown to be in refinement of the identified QTL, candidate gene and SNP discovery, understanding gene-environment and gene-gene interactions, detection of candidate regulator genes/eQTL, discriminating multiple QTL/eQTL, and detection of pleiotropic QTL/eQTL, in addition to its use in reconstructing regulatory networks. The potential uses in animal breeding are direct selection on heritable gene expression measures, termed "expression assisted selection," and genetical genomic selection of both QTL and eQTL based on breeding values of the respective genes, termed "expression-assisted evaluation."
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.