ArticleHuman genetics2006
Variants in the HEPSIN gene are associated with prostate cancer in men of European origin.
Article in Human genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Clinical Significance of Hepsin and Underlying Signaling Pathways in Prostate Cancer.Biomolecules · 2022Review
- Dysregulation of Type II Transmembrane Serine Proteases and Ligand-Dependent Activation of MET in Urological Cancers.International journal of molecular sciences · 2020Review
- Cell surface-anchored serine proteases in cancer progression and metastasis.Cancer metastasis reviews · 2019Review
- The role of type II transmembrane serine protease-mediated signaling in cancer.The FEBS journal · 2017Review
- Targeted inhibition of cell-surface serine protease Hepsin blocks prostate cancer bone metastasis.Oncotarget · 2014Article
- Article
- Variants in the HEPSIN gene are associated with susceptibility to prostate cancer.Prostate cancer and prostatic diseases · 2012Article
- Finding minimum gene subsets with heuristic breadth-first search algorithm for robust tumor classification.BMC bioinformatics · 2012Article
- An integrated approach for identifying wrongly labelled samples when performing classification in microarray data.PloS one · 2012Article
- Regulators of gene expression as biomarkers for prostate cancer.American journal of cancer research · 2012Article
- Association of hepsin gene variants with prostate cancer risk and prognosis.The Prostate · 2010Article
- Common variants in 8q24 are associated with risk for prostate cancer and tumor aggressiveness in men of European ancestry.The Prostate · 2009Article
- RankAggreg, an R package for weighted rank aggregation.BMC bioinformatics · 2009Article
- Tagging SNPs in the kallikrein genes 3 and 2 on 19q13 and their associations with prostate cancer in men of European origin.Human genetics · 2007Article
- Genome-wide linkage scan of prostate cancer Gleason score and confirmation of chromosome 19q.Human genetics · 2007Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is considerable evidence that genetic factors are involved in prostate cancer susceptibility. We have studied the association of 11 single nucleotide polymorphisms (SNPs) in the HEPSIN gene (HPN) with prostate cancer in men of European ancestry. HPN is a likely candidate in prostate cancer susceptibility, as it encodes a transmembrane cell surface serum protease, which is overexpressed in prostate cancer; HPN is also located on 19q11-q13.2, where linkage is found with prostate cancer susceptibility. In this case-control association study (590 men with histologically verified prostate cancer and 576 unrelated controls, all of European descent), we find significant allele frequency differences between cases and controls at five SNPs that are located contiguously within the gene. A major 11-locus haplotype is significantly associated, which provides further support that HPN is a potentially important candidate gene involved in prostate cancer susceptibility. Association of one of the SNPs with Gleason score is also suggestive of a plausible role of HPN in tumor aggressiveness.
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