SynthesisEuropean archives of psychiatry and clinical neuroscience2006
Evidence for beneficial effects of antidepressants on suicidality in depressive patients: a systematic review.
Synthesis in European archives of psychiatry and clinical neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- A Youth Suicide Prevention Plan for Canada: A Systematic Review of Reviews.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2015Pooled it
- Is there evidence for negative effects of antidepressants on suicidality in depressive patients? A systematic review.European archives of psychiatry and clinical neuroscience · 2006Pooled it
- Major Depression and the Degree of Suicidality: Results of the European Group for the Study of Resistant Depression (GSRD).The international journal of neuropsychopharmacology · 2018Article
- "Does Ketamine Have Rapid Anti-Suicidal Ideation Effects?"Current treatment options in psychiatry · 2015Article
- Suicide in Hungary-epidemiological and clinical perspectives.Annals of general psychiatry · 2013Article
- General and comparative efficacy and effectiveness of antidepressants in the acute treatment of depressive disorders: a report by the WPA section of pharmacopsychiatry.European archives of psychiatry and clinical neuroscience · 2011Article
- Antidepressants and Suicide Risk: A Comprehensive Overview.Pharmaceuticals (Basel, Switzerland) · 2010Review
- Antidepressant-induced suicidality: an update.CNS neuroscience & therapeutics · 2010Review
- The emerging modern face of mood disorders: a didactic editorial with a detailed presentation of data and definitions.Annals of general psychiatry · 2010Article
- Do SSRIs or antidepressants in general increase suicidality? WPA Section on Pharmacopsychiatry: consensus statement.European archives of psychiatry and clinical neuroscience · 2008Review
- Suicide victims' contacts with physicians during the year before death.European archives of psychiatry and clinical neuroscience · 2007Article
- Comparison of clinicodemographic characteristics in patients with selective serotonin reuptake inhibitors poisoning: A cross-sectional study.Medical journal, Armed Forces IndiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of antidepressants in suicide prevention is a major public health question, given the high prevalence of both depression and depression-related suicidality. Therefore all means available should be utilised to clarify the influence of antidepressants on suicidality. This paper gives a comprehensive overview of the positive effects of antidepressants on suicidality. In the first section, principal methodological issues related to suicidology in general as well as to clinical and epidemiological studies that investigate the influence of antidepressants on suicidality are discussed. In the second section, the results of controlled clinical studies on the efficacy of antidepressants in suicidality are presented. The third section reports on the results of other types of studies, especially epidemiological studies. Altogether, there seems to be reasonable evidence from different research approaches that antidepressants are able to reduce suicidal ideation and also suicidal behaviour in depressive patients. While the evidence for the beneficial effect on suicidal ideation comes from randomised control group studies, some of which used a placebo arm, the evidence for the prophylactic effect on suicidal behaviour, especially suicide, was primarily obtained from well-designed epidemiological studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.