Evidence map›Paper›PMID 16783499›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2006

Serum BDNF, TNF-alpha and IL-1beta levels in dementia patients: comparison between Alzheimer's disease and vascular dementia.

Chie Yasutake, Kenji Kuroda, Toshio Yanagawa, Takehiko Okamura, Hiroshi Yoneda

Erratum issuedAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 85 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 8 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 8 syntheses or guidelines pooled it, 175 citations in OpenAlex.

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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Chie YasutakeDepartment of Neuropsychiatry, Osaka Medical College, Daigakumachi 2-7, Takatsuki, Osaka, Japan. yasutake@mips.ne.jp
Kenji Kuroda
Toshio Yanagawa
Takehiko Okamura
Hiroshi Yoneda
Osaka Medical and Pharmaceutical University · JPTakatsuki General Hospital · JPHannan University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurotrophins such as the brain-derived neurotrophic factor (BDNF) are reportedly related to the pathogenesis of Alzheimer's disease (AD). Several studies have revealed an alteration in BDNF expression in the postmortem brains of AD patients. BDNF has great potential as a therapeutic agent because of its ability to cross the blood-brain barrier and due to its wide in vivo distribution. However, little is known about in vivo BDNF in dementia patients. Moreover, the immunological function of neurotrophins such as BDNF has received great interest. Therefore, we investigated the serum levels of BDNF and cytokines such as TNF-alpha and IL-1beta in dementia patients by the enzyme-linked immunosorbent assay (ELISA). The following subjects were included in this study: 60 AD patients, 60 vascular dementia (VaD) patients and 33 healthy controls. AD and VaD patients were matched for age, gender and severity of dementia. Serum BDNF levels in AD patients were significantly lower than those in VaD patients and controls. TNF-alpha and IL-1beta levels showed no significant difference among the three groups. In the dementia groups, neither the TNF-alpha nor the IL-1beta levels correlated with the BDNF levels. Our results suggest that BDNF may play a pathological role in some cases of AD.

Indexed as

AgedAged, 80 and overAgingAlzheimer DiseaseBrain-Derived Neurotrophic FactorBrain IschemiaDementiaDementia, VascularFemaleHumansInterleukin-1betaMaleMiddle AgedNeuropsychological TestsTumor Necrosis Factor-alphaBrain-Derived Neurotrophic FactorInterleukin-1betaTumor Necrosis Factor-alpha

Identifiers

PMID16783499
OpenAlexW2008128503

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.