ArticleDiabetologia2006
Suitability of human juvenile pancreatic islets for clinical use.
Article in Diabetologia, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 69 citations in OpenAlex.
- Total Pancreatectomy With Islet Autotransplantation Resolves Pain in Young Children With Severe Chronic Pancreatitis.Journal of pediatric gastroenterology and nutrition · 2017Trial
- Mapping histologic and functional maturation of human endocrine pancreas across early postnatal periods.Nature communications · 2026Article
- Distal pancreatectomy with autologous islet transplantation in chronic pancreatitis patients: First case series from India.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2018Article
- The Future of Islet Transplantation Is Now.Frontiers in medicine · 2018Review
- Fluorogenic Peptide Substrate for Quantification of Bacterial Enzyme Activities.Scientific reports · 2017Article
- Enzyme Development for Human Islet Isolation: Five Decades of Progress or Stagnation?The review of diabetic studies : RDS · 2017Review
- Single-Cell Transcriptomics of the Human Endocrine Pancreas.Diabetes · 2016Article
- Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion.Science (New York, N.Y.) · 2016Article
- Dynamics and Regulation of Insulin Secretion in Pancreatic Islets from Normal Young Children.PloS one · 2016Article
- Factors Predicting Outcomes After a Total Pancreatectomy and Islet Autotransplantation Lessons Learned From Over 500 Cases.Annals of surgery · 2015Article
- The Choice of Enzyme for Human Pancreas Digestion is a Critical Factor for Increasing the Success of Islet Isolation.Transplantation direct · 2015Article
- Total pancreatectomy and islet autotransplantation in children for chronic pancreatitis: indication, surgical techniques, postoperative management, and long-term outcomes.Annals of surgery · 2014Article
- Long-term outcomes of total pancreatectomy and islet auto transplantation for hereditary/genetic pancreatitis.Journal of the American College of Surgeons · 2014Article
- Proposed thresholds for pancreatic tissue volume for safe intraportal islet autotransplantation after total pancreatectomy.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2013Article
- Isolation of human islets for autologous islet transplantation in children and adolescents with chronic pancreatitis.Journal of transplantation · 2012Article
- Article
- Phagocytosis of enterovirus-infected pancreatic beta-cells triggers innate immune responses in human dendritic cells.Diabetes · 2010Article
- Multicenter analysis of novel and established variables associated with successful human islet isolation outcomes.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2010Article
- Regulation of copper transport in Arabidopsis thaliana: a biochemical oscillator?Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2010Review
- Human islet isolation for autologous transplantation: comparison of yield and function using SERVA/Nordmark versus Roche enzymes.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2009Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisThe limited availability of deceased donor pancreases suitable for pancreas and islet transplantation calls for a broader utilisation of donor tissue for transplantation purposes. Young donors, representing, fortunately, a minor but significant pool of individuals, have been largely under-employed, mainly because of anatomical and functional incompatibilities with potential recipients. For islet transplantation, the isolation of pancreatic islets from young donors rarely occurs, because of technical problems. As a result of the peculiar characteristics of young donor pancreases, the standard isolation procedure does not allow efficient separation of the islets from the surrounding exocrine tissue, and favours the generation of mantled islets. Nonetheless, young donor islets offer high qualitative and clinically appealing characteristics. SUBJECTS AND
methodsWe standardised a modified methodology to obtain purified and mantle-free human islets from young donors. This method principally involves efficient delivery of isolation enzyme with reduced mechanical disruption of the pancreas combined with additional filtration steps.
resultsWe were able to obtain purified and mantle-free human islets from donors as young as 6 months of age with good morphological and functional properties. The good qualitative characteristics of the islets, evidenced in vitro, were proven in vivo, as they were qualitatively superior to islets of older donors in transplantation studies. CONCLUSIONS/
interpretationThis study justifies the utilisation of islets derived from young donors for islet transplantation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.