ArticleJournal of neuropathology and experimental neurology2006
High-resolution array-based comparative genomic hybridization of medulloblastomas and supratentorial primitive neuroectodermal tumors.
Article in Journal of neuropathology and experimental neurology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Is there a role for high dose chemotherapy with hematopoietic stem cell rescue in patients with relapsed supratentorial PNET?Journal of neuro-oncology · 2012Pooled it
- Outcome and prognostic factors for children with supratentorial primitive neuroectodermal tumors treated with carboplatin during radiotherapy: a report from the Children's Oncology Group.Pediatric blood & cancer · 2015Trial
- Array comparative genomic hybridisation in haematological malignancies: A comprehensive review.African journal of laboratory medicine · 2026Review
- Molecular Classification and Management of Rare Pediatric Embryonal Brain Tumors.Current oncology reports · 2018Review
- Clinical outcomes of children and adults with central nervous system primitive neuroectodermal tumor.Journal of neuro-oncology · 2014Article
- Amplification of 2p as a genomic marker for transformation in lymphoma.Genes, chromosomes & cancer · 2014Article
- Mutation and expression analysis in medulloblastoma yields prognostic variants and a putative mechanism of disease for i17q tumors.Acta neuropathologica communications · 2014Article
- MYCN amplification predicts poor outcome for patients with supratentorial primitive neuroectodermal tumors of the central nervous system .Neuro-oncology · 2014Article
- The role of the WNT/β-catenin pathway in central nervous system primitive neuroectodermal tumours (CNS PNETs).British journal of cancer · 2013Article
- Molecular markers in pediatric neuro-oncology.Neuro-oncology · 2012Review
- Early recurrence in standard-risk medulloblastoma patients with the common idic(17)(p11.2) rearrangement.Neuro-oncology · 2012Article
- Novel amplifications in pediatric medulloblastoma identified by genome-wide copy number profiling.Journal of neuro-oncology · 2012Article
- Prognostic classification of pediatric medulloblastoma based on chromosome 17p loss, expression of MYCC and MYCN, and Wnt pathway activation.Neuro-oncology · 2012Article
- Article
- Genome-wide molecular characterization of central nervous system primitive neuroectodermal tumor and pineoblastoma.Neuro-oncology · 2011Article
- KIT expression and methylation in medulloblastoma and PNET cell lines and tumors.Journal of neuro-oncology · 2011Article
- Chromosome 17 alterations identify good-risk and poor-risk tumors independently of clinical factors in medulloblastoma.Neuro-oncology · 2011Article
- Molecular diagnostics in embryonal brain tumors.Brain pathology (Zurich, Switzerland) · 2011Review
- MYB upregulation and genetic aberrations in a subset of pediatric low-grade gliomas.Acta neuropathologica · 2010Article
- Molecular diagnostics of CNS embryonal tumors.Acta neuropathologica · 2010Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Medulloblastomas and supratentorial primitive neuroectodermal tumors are aggressive childhood tumors. We report our findings using array comparative genomic hybridization (CGH) on a whole-genome BAC/PAC/cosmid array with a median clone separation of 0.97 Mb to study 34 medulloblastomas and 7 supratentorial primitive neuroectodermal tumors. Array CGH allowed identification and mapping of numerous novel, small regions of copy number change to genomic sequence in addition to the large regions already known from previous studies. Novel amplifications were identified, some encompassing oncogenes MYCL1, PDGFRA, KIT, and MYB not previously reported to show amplification in these tumors. In addition, one supratentorial primitive neuroectodermal tumor had lost both copies of the tumor-suppressor genes CDKN2A and CDKN2B. Ten medulloblastomas had findings suggestive of isochromosome 17q. In contrast to previous reports using conventional CGH, array CGH identified 3 distinct breakpoints in these cases: Ch 17: 17940393-19251679 (17p11.2, n = 6), Ch 17: 20111990-23308272 (17p11.2-17q11.2, n = 4), and Ch 17: 38425359-39091575 (17q21.31, n = 1). Significant differences were found in the patterns of copy number change between medulloblastomas and supratentorial primitive neuroectodermal tumors, providing further evidence that these tumors are genetically distinct despite their morphologic and behavioral similarities.
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