ArticleGenetics2006
The relative roles of three DNA repair pathways in preventing Caenorhabditis elegans mutation accumulation.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Evaluation of mutagenic susceptibility of different stages in germ cell development of Caenorhabditis elegans using whole genome sequencing.Archives of toxicology · 2023Article
- DNA repair, recombination, and damage signaling.Genetics · 2022Review
- Review
- Sulfamethoxazole-Altered Transcriptomein Green AlgaFrontiers in microbiology · 2021Article
- Pan-cancer analysis of advanced patient tumors reveals interactions between therapy and genomic landscapes.Nature cancer · 2020Article
- Adaptive Evolution under Extreme Genetic Drift in Oxidatively Stressed Caenorhabditis elegans.Genome biology and evolution · 2017Article
- Expression of human Bcl-xL (Ser49) and (Ser62) mutants in Caenorhabditis elegans causes germline defects and aneuploidy.PloS one · 2017Article
- Quantification of in vivo progenitor mutation accrual with ultra-low error rate and minimal input DNA using SIP-HAVA-seq.Genome research · 2016Article
- Integrative Genomics and Transcriptomics Analysis Reveals Potential Mechanisms for Favorable Prognosis of Patients with HPV-Positive Head and Neck Carcinomas.Scientific reports · 2016Article
- Genome-Wide Estimates of Mutation Rates and Spectrum in Schizosaccharomyces pombe Indicate CpG Sites are Highly Mutagenic Despite the Absence of DNA Methylation.G3 (Bethesda, Md.) · 2015Article
- Distinct Phenotypes Caused by Mutation of MSH2 in Trypanosome Insect and Mammalian Life Cycle Forms Are Associated with Parasite Adaptation to Oxidative Stress.PLoS neglected tropical diseases · 2015Article
- Having a direct look: analysis of DNA damage and repair mechanisms by next generation sequencing.Experimental cell research · 2014Review
- C. elegans whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency.Genome research · 2014Article
- Article
- DNA damage leads to progressive replicative decline but extends the life span of long-lived mutant animals.Cell death and differentiation · 2013Article
- A systems approach defining constraints of the genome architecture on lineage selection and evolvability during somatic cancer evolution.Biology open · 2013Article
- Evolution of a higher intracellular oxidizing environment in Caenorhabditis elegans under relaxed selection.PloS one · 2013Article
- Article
- A two-tiered compensatory response to loss of DNA repair modulates aging and stress response pathways.Aging · 2010Article
- Nucleotide excision repair genes are expressed at low levels and are not detectably inducible in Caenorhabditis elegans somatic tissues, but their function is required for normal adult life after UVC exposure.Mutation research · 2010Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Mutation is a central biological process whose rates and spectra are influenced by a variety of complex and interacting forces. Although DNA repair pathways are generally known to play key roles in maintaining genetic stability, much remains to be understood about the relative roles of different pathways in preventing the accumulation of mutations and the extent of heterogeneity in pathway-specific repair efficiencies across different genomic regions. In this study we examine mutation processes in base excision repair-deficient (nth-1) and nucleotide excision repair-deficient (xpa-1) Caenorhabditis elegans mutation-accumulation (MA) lines across 24 regions of the genome and compare our observations to previous data from mismatch repair-deficient (msh-2 and msh-6) and wild-type (N2) MA lines. Drastic variation in both average and locus-specific mutation rates, ranging two orders of magnitude for the latter, was detected among the four sets of repair-deficient MA lines. Our work provides critical insights into the relative roles of three DNA repair pathways in preventing C. elegans mutation accumulation and provides evidence for the presence of pathway-specific DNA repair territories in the C. elegans genome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.