ArticleGenetics2006
Nucleotide variation and haplotype diversity in a 10-kb noncoding region in three continental human populations.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The dystrobrevin-binding protein 1 gene: features and networks.Molecular psychiatry · 2009Pooled it
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- Avian Toll-like receptor allelic diversity far exceeds human polymorphism: an insight from domestic chicken breeds.Scientific reports · 2018Article
- A high density GBS map of bread wheat and its application for dissecting complex disease resistance traits.BMC genomics · 2015Article
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- Divergence, demography and gene loss along the human lineage.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Article
- The evolution of human genetic and phenotypic variation in Africa.Current biology : CB · 2010Review
- A history of recurrent positive selection at the toll-like receptor 5 in primates.Molecular biology and evolution · 2009Article
- Controlling type-I error of the McDonald-Kreitman test in genomewide scans for selection on noncoding DNA.Genetics · 2008Article
- Decoding of superimposed traces produced by direct sequencing of heterozygous indels.PLoS computational biology · 2008Article
- African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping.Annual review of genomics and human genetics · 2008Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Noncoding regions are usually less subject to natural selection than coding regions and so may be more useful for studying human evolution. The recent surveys of worldwide DNA variation in four 10-kb noncoding regions revealed many interesting but also some incongruent patterns. Here we studied another 10-kb noncoding region, which is in 6p22. Sixty-six single-nucleotide polymorphisms were found among the 122 worldwide human sequences, resulting in 46 genotypes, from which 48 haplotypes were inferred. The distribution patterns of DNA variation, genotypes, and haplotypes suggest rapid population expansion in relatively recent times. The levels of polymorphism within human populations and divergence between humans and chimpanzees at this locus were generally similar to those for the other four noncoding regions. Fu and Li's tests rejected the neutrality assumption in the total sample and in the African sample but Tajima's test did not reject neutrality. A detailed examination of the contributions of various types of mutations to the parameters used in the neutrality tests clarified the discrepancy between these test results. The age estimates suggest a relatively young history in this region. Combining three autosomal noncoding regions, we estimated the long-term effective population size of humans to be 11,000 +/- 2800 using Tajima's estimator and 17,600 +/- 4700 using Watterson's estimator and the age of the most recent common ancestor to be 860,000 +/- 258,000 years ago.
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