ArticleBiophysical journal2006
Localization of linker histone in chromatosomes by cryo-atomic force microscopy.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Characterization of nucleosome unwrapping within chromatin fibers using magnetic tweezers.Biophysical journal · 2014Article
- DNA and nucleosomes direct distinct folding of a linker histone H1 C-terminal domain.Nucleic acids research · 2012Article
- Modeling studies of chromatin fiber structure as a function of DNA linker length.Journal of molecular biology · 2010Article
- Mesoscale simulations of two nucleosome-repeat length oligonucleosomes.Physical chemistry chemical physics : PCCP · 2009Article
- The human IgM pentamer is a mushroom-shaped molecule with a flexural bias.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Linker histone H1 is present in centromeric chromatin of living human cells next to inner kinetochore proteins.Nucleic acids research · 2009Article
- A tale of tails: how histone tails mediate chromatin compaction in different salt and linker histone environments.The journal of physical chemistry. A · 2009Article
- ACF catalyses chromatosome movements in chromatin fibres.The EMBO journal · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Linker histones play a fundamental role in determining higher order chromatin structure as a consequence of their association with nucelosomal DNA. Yet the locations and structural consequences of linker histone binding are still enigmatic. Here, using cryo-atomic force microscopy, we show that the linker histone H5 in native chromatin and in chromatosomes reconstituted on the 5S rDNA template is located at the dyad of the nucleosome core particle, within the "stem" structure. Direct measurement also indicates that the length of free linker DNA between chromatosomes in native chromatin is approximately 30 bp, slightly shorter than that estimated from nuclease digestion assays.
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Registered trials
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