ArticleBiophysical journal2006
Reconstitution of the Frank-Starling mechanism in engineered heart tissues.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Pulling Frank-Starling into another dimension.Biophysical journal · 2025Article
- Geometry and length control of 3D engineered heart tissues using direct laser writing.Lab on a chip · 2024Article
- Circulating re-entrant waves promote maturation of hiPSC-derived cardiomyocytes in self-organized tissue ring.Communications biology · 2020Article
- Engineering Biomaterials and Approaches for Mechanical Stretching of Cells in Three Dimensions.Frontiers in bioengineering and biotechnology · 2020Review
- Afterload promotes maturation of human induced pluripotent stem cell derived cardiomyocytes in engineered heart tissues.Journal of molecular and cellular cardiology · 2018Article
- Genetic and Tissue Engineering Approaches to Modeling the Mechanics of Human Heart Failure for Drug Discovery.Frontiers in cardiovascular medicine · 2018Review
- Fibroblasts Slow Conduction Velocity in a Reconstituted Tissue Model of Fibrotic Cardiomyopathy.ACS biomaterials science & engineering · 2017Article
- Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment.Chemical reviews · 2017Review
- Septic cardiomyopathy: evidence for a reduced force-generating capacity of human atrial myocardium in acute infective endocarditis.Innovative surgical sciences · 2017Article
- I-Wire Heart-on-a-Chip I: Three-dimensional cardiac tissue constructs for physiology and pharmacology.Acta biomaterialia · 2017Article
- Tissue constructs: platforms for basic research and drug discovery.Interface focus · 2016Article
- Improving Cardiac Action Potential Measurements: 2D and 3D Cell Culture.Journal of bioengineering & biomedical science · 2015Article
- Mimicking isovolumic contraction with combined electromechanical stimulation improves the development of engineered cardiac constructs.Tissue engineering. Part A · 2014Article
- Biomechanics of cardiac electromechanical coupling and mechanoelectric feedback.Journal of biomechanical engineering · 2014Review
- Contractile and electrophysiologic characterization of optimized self-organizing engineered heart tissue.The Annals of thoracic surgery · 2012Article
- Strategies for tissue engineering cardiac constructs to affect functional repair following myocardial infarction.Journal of cardiovascular translational research · 2011Review
- Neonatal mouse-derived engineered cardiac tissue: a novel model system for studying genetic heart disease.Circulation research · 2011Article
- Viscoelastic characteristics of contracted collagen gels populated with rat fibroblasts or cardiomyocytes.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2010Article
- Whole cell mechanics of contractile fibroblasts: relations between effective cellular and extracellular matrix moduli.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2010Review
- Engineered heart tissue: high throughput platform for dissection of complex diseases.Journal of cardiovascular translational research · 2008Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
According to the Frank-Starling mechanism, as the heart is stretched, it increases its contraction force. Reconstitution of the Frank-Starling mechanism is an important milestone for producing functional heart tissue constructs. Spontaneously contracting engineered heart tissues (EHTs) were reconstituted by growing dissociated chicken embryo cardiomyocytes in collagen matrices. Twitch and baseline tensions were recorded at precisely controlled levels of tissue strain. The EHTs showed a steep increase in twitch tension from 0.47 +/- 0.02 to 0.91 +/- 0.02 mN/mm2 as they were stretched at a constant rate (2.67% per min) from 86% to 100% of the length at which maximum twitch force was exerted. In response to a sudden stretch (3.3%), the twitch tension increased gradually (approximately 60 s) in a Gd3+-sensitive manner, suggesting the presence of stretch-activated Ca2+ channels. A large difference in baseline tension between lengthening (loading) and shortening (unloading) was also recorded. Disruption of nonsarcomeric actin filaments by cytochalasin D and latrunculin B decreased this difference. A simple mechanical model interprets these results in terms of mechanical connections between myocytes and nonmuscle cells. The experimental results strongly suggest that regulation of twitch tension in EHTs is similar to that of natural myocardium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.