ReviewSchizophrenia bulletin2006
Generalized and specific cognitive performance in clinical high-risk cohorts: a review highlighting potential vulnerability markers for psychosis.
Review in Schizophrenia bulletin, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
92 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cognition and resting-state functional connectivity in schizophrenia.Neuroscience and biobehavioral reviews · 2016Pooled it
- Cognitive impairment in affective psychoses: a meta-analysis.Schizophrenia bulletin · 2010Pooled it
- From the psychosis prodrome to the first-episode of psychosis: No evidence of a cognitive decline.Journal of psychiatric research · 2018Trial
- Trial
- Trial
- The effect of state anxiety on paranoid ideation and jumping to conclusions. An experimental investigation.Schizophrenia bulletin · 2010Trial
- Cognitive subtypes and brain network differences in antipsychotic-naïve first-episode psychosis.Schizophrenia (Heidelberg, Germany) · 2026Article
- Impairments in biological motion perception reflect affective disturbance in individuals at clinical high-risk for psychosis.Schizophrenia research. Cognition · 2026Article
- Cognitive Deficits in Schizophrenia: Brain Deorganization and Neurorehabilitation.Advances in experimental medicine and biology · 2026Review
- Reduced interpersonal head synchrony in youth at clinical high risk for psychosis.Psychological medicine · 2025Article
- Anatomical variations in the insular cortex in individuals at a clinical high-risk state for psychosis and patients with schizophrenia.Frontiers in psychiatry · 2023Article
- Atypical prediction error learning is associated with prodromal symptoms in individuals at clinical high risk for psychosis.Schizophrenia (Heidelberg, Germany) · 2022Article
- Relating self-disorders to neurocognitive and psychopathological measures in first-episode schizophrenia.Early intervention in psychiatry · 2022Article
- Associations between symptom and neurocognitive dimensions in clinical high risk for psychosis.Schizophrenia research. Cognition · 2022Article
- Cognitive predictors of longitudinal positive symptom course in clinical high risk for psychosis.Schizophrenia research. Cognition · 2021Article
- Article
- Smoking Is Related to Reduced Motivation, But Not Global Cognition, in the First Two Years of Treatment for First Episode Psychosis.Journal of clinical medicine · 2021Article
- Genetic influences on externalizing psychopathology overlap with cognitive functioning and show developmental variation.European psychiatry : the journal of the Association of European Psychiatrists · 2021Article
- Grey-matter abnormalities in clinical high-risk participants for psychosis.Schizophrenia research · 2020Article
- Correlations between age, biomedical variables, and cognition in patients with schizophrenia.Schizophrenia research. Cognition · 2020Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive deficits are a core feature of established psychotic illnesses. However, the association between cognition and emerging psychosis is less understood. While there is some evidence that cognitive deficits are present prior to the onset of psychosis, findings are not consistent. In this article we provide an overview of the more general cognitive findings available from genetic high-risk studies, retrospective studies, and birth cohort studies. We then focus the review on neuropsychological performance in clinically "at-risk" groups. Overall, general cognitive ability as assessed by established batteries appears to remain relatively intact in these ultra-high risk cohorts and is a poor predictor close to illness onset relative to other vulnerability factors. Further decline may occur with illness progression, more consistent with state relative to trait factors. In addition, most established cognitive tasks involve several relatively discrete cognitive subprocesses, where findings from general batteries of subtests may mask specific deficits. In this context, our review suggests that relatively specific olfactory identification and spatial working memory deficits exist prior to illness onset and may be more potent trait markers for psychosis than cognitively dense tasks such as verbal memory. Suggestions for further research address the importance of standardization of inclusion criteria and the maintenance of basic neuropsychological assessment to allow better comparison of findings across centers. Further, in order to better understand the aetiopathology of cognitive dysfunction in psychosis, more experimental, hypothesis-driven measures of discrete cognitive processes are required. Delineation of the relationship between specific cognitive ability and symptoms from data-driven approaches may improve our understanding of the role of cognition during psychosis onset.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.