ArticleNeurotoxicity research2006
Upregulation of brain-derived neurotrophic factor in the sensory pathway by selective motor nerve injury in adult rats.
Article in Neurotoxicity research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Neurotrophins in Peripheral Neuropathy: Exploring Pathophysiological Mechanisms and Emerging Therapeutic Opportunities.CNS & neurological disorders drug targets · 2025Review
- The Endogenous Pain Modulatory System as a Healing Mechanism: A Proposal on How to Measure and Modulate It.NeuroSci · 2024Review
- The dorsal root ganglion as a target for neurorestoration in neuropathic pain.Neural regeneration research · 2024Review
- Contribution of COMT and BDNF Genotype and Expression to the Risk of Transition From Acute to Chronic Low Back Pain.The Clinical journal of pain · 2020Article
- Effects of SHINBARO2 on Rat Models of Lumbar Spinal Stenosis.Mediators of inflammation · 2019Article
- Brain-derived neurotrophic factor derived from sensory neurons plays a critical role in chronic pain.Brain : a journal of neurology · 2018Article
- An exploratory study of BDNF and oxidative stress marker alterations in subacute and chronic stroke patients affected by neuropathic pain.Journal of neural transmission (Vienna, Austria : 1996) · 2017Article
- Activation of neurotrophins in lumbar dorsal root probably contributes to neuropathic pain after spinal nerve ligation.Iranian journal of basic medical sciences · 2017Article
- Peripheral nerve injury modulates neurotrophin signaling in the peripheral and central nervous system.Molecular neurobiology · 2014Review
- Role of neurotrophins in neuropathic pain.Current neuropharmacology · 2011Article
- In vivo evidence that truncated trkB.T1 participates in nociception.Molecular pain · 2009Article
- Treating skeletal pain: limitations of conventional anti-inflammatory drugs, and anti-neurotrophic factor as a possible alternative.Nature clinical practice. Rheumatology · 2009Review
- Peripherally-derived BDNF promotes regeneration of ascending sensory neurons after spinal cord injury.PloS one · 2008Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Selective motor nerve injury by lumbar 5 ventral root transection (L5 VRT) induces neuropathic pain, but the underlying mechanisms remain unknown. Previously, increased expression and secretion of brain-derived neurotrophic factor (BDNF) had been implicated in injury-induced neuropathic pain in the sensory system. In this study, as a step to examine potential roles of BDNF in L5 VRT-induced neuropathic pain, we investigated BDNF gene and protein expression in adult rats with L5 VRT. L5 VRT induced a dramatic upregulation of BDNF mRNA in intact sensory neurons in the ipsilateral L5 dorsal root ganglia (DRG), in non-neuronal cells in the ipsilateral sciatic nerve, and in motoneurons in the ipsilateral spinal cord. L5 VRT also induced de novo synthesis of BDNF mRNA in spinal dorsal horn neurons and in glial cells in the white matter of the ipsilateral spinal cord. Consistent with the mRNA expression pattern, BDNF protein was also mainly upregulated in all populations of sensory neurons in the ipsilateral L5 DRG and in spinal neurons and glia. Quantitative analysis by ELISA showed that the BDNF content in the DRG and sciatic nerve peaked on day 1 and remained elevated 14 days after L5 VRT. These results suggest that increased BDNF expression in intact primary sensory neurons and spinal cord may be an important factor in the induction of neuropathic pain without axotomy of sensory neurons.
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