ArticleBiochemical and biophysical research communications2006
Regulation of Stat1 protein expression by phenylalanine 172 in the coiled-coil domain.
Article in Biochemical and biophysical research communications, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Novel reporter systems to detect cold and osmotic stress responses.Biology methods & protocols · 2025Article
- ADAR1 Suppresses Interferon Signaling in Gastric Cancer Cells by MicroRNA-302a-Mediated IRF9/STAT1 Regulation.International journal of molecular sciences · 2020Article
- Identification of proteins associated with an IFNγ-responsive promoter by a retroviral expression system for enChIP using CRISPR.PloS one · 2014Article
- Inborn errors of human STAT1: allelic heterogeneity governs the diversity of immunological and infectious phenotypes.Current opinion in immunology · 2012Review
- Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis.The Journal of experimental medicine · 2011Article
- Temporal regulation of Stat5 activity in determination of cell differentiation program.Biochemical and biophysical research communications · 2007Article
- Cell type-specific roles of Jak3 in IL-2-induced proliferative signal transduction.Biochemical and biophysical research communications · 2007Article
- Redundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclon.FEBS letters · 2007Article
- Nuclear translocation of 2-amino-3-ketobutyrate coenzyme A ligase by cold and osmotic stress.Cell stress & chaperones · 2007Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Stat1 plays an essential role in signal transduction and gene expression of various cytokines including interferons (IFNs). Although the mechanism of cytokine-induced activation of Stat1 and transcriptional regulation of Stat1 gene expression have been established, post-transcriptional regulation of Stat1 protein expression is not fully understood. Here, we report identification of a mutant of Stat1 that has decreased expression levels by using inducible translocation trap (ITT), a reporter gene-based detection system of nuclear translocation. The substitution of serine for phenylalanine 172 (F172S) in the coiled-coil domain causes marked decrease in Stat1 protein expression in various cell lines without decreasing its mRNA levels. Our results suggest that the decrease is caused by translational/post-translational mechanisms independent of proteasome machinery. These results suggest a novel potential mechanism of determination of specificity of Stat proteins and showed that the ITT system is a powerful technique to identify mutants of nuclear translocating signal transducers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.