ArticleDevelopmental biology2006
Regulation of the retinal determination gene dachshund in the embryonic head and developing eye of Drosophila.
Article in Developmental biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Modulating the levels and activity of the retinal determination network is sufficient to induce the specification of distinct tissue fates in Drosophila.Development (Cambridge, England) · 2025Article
- Dachshund and C-terminal Binding Protein bind directly duringmicroPublication biology · 2024Article
- Mutations in abnormal spindle disrupt temporal transcription factor expression and trigger immune responses in the Drosophila brain.Genetics · 2023Article
- Human eye conditions: insights from the fly eye.Human genetics · 2019Review
- Dynamic genome wide expression profiling of Drosophila head development reveals a novel role of Hunchback in retinal glia cell development and blood-brain barrier integrity.PLoS genetics · 2018Article
- LTR sequence of the MDG4 retrotransposon contains the MAD protein binding site that affects the east-dependent repression.Doklady. Biochemistry and biophysics · 2017Article
- Master regulators in development: Views from the Drosophila retinal determination and mammalian pluripotency gene networks.Developmental biology · 2017Review
- Initiation of diverse epigenetic states during nuclear programming of the Drosophila body plan.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Distinct Biochemical Activities of Eyes absent During Drosophila Eye Development.Scientific reports · 2016Article
- The development of face orienting mechanisms in infants at-risk for autism.Behavioural brain research · 2013Article
- In-frame mutations in exon 1 of SKI cause dominant Shprintzen-Goldberg syndrome.American journal of human genetics · 2012Article
- A bow-tie genetic architecture for morphogenesis suggested by a genome-wide RNAi screen in Caenorhabditis elegans.PLoS genetics · 2011Article
- The retinal determination gene eyes absent is regulated by the EGF receptor pathway throughout development in Drosophila.Genetics · 2010Article
- Differential recruitment of limb patterning genes during development and diversification of beetle horns.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Position dependent responses to discontinuities in the retinal determination network.Developmental biology · 2009Article
- Drosophila nemo promotes eye specification directed by the retinal determination gene network.Genetics · 2008Article
- Identification of transcriptional targets of the dual-function transcription factor/phosphatase eyes absent.Developmental biology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The retinal determination gene dachshund is distantly related to the family of Ski/Sno proto-oncogenes and influences the development of a wide range of tissues including the embryonic head, optic lobes, brain, central nervous system as well as the post-embryonic leg, wing, genital and eye-antennal discs. We were interested in the regulatory mechanisms that control the dynamic expression pattern of dachshund and in this report we set out to ascertain how the transcription of dachshund is modulated in the embryonic head and developing eye-antennal imaginal disc. We demonstrate that the TGFbeta signaling cascade, the transcription factor zerknullt and several other patterning genes prevent dachshund from being expressed inappropriately within the embryonic head. Additionally, we show that several members of the eye specification cascade influence the transcription of dachshund during normal and ectopic eye development. Our results suggest that dachshund is regulated by a complex combinatorial code of transcription factors and signaling pathways. Unraveling this code may lead to an understanding of how dachshund regulates the development of many diverse tissue types including the eye.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.