ArticleRespiratory research2006
Marked stem cell factor expression in the airways of lung transplant recipients.
Article in Respiratory research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 17 citations in OpenAlex.
- Role of Mast Cells and Type 2 Innate Lymphoid (ILC2) Cells in Lung Transplantation.Journal of immunology research · 2018Review
- New Role of Adult Lung c-kitMediators of inflammation · 2016Article
- Role of stem cell factor and bone marrow-derived fibroblasts in airway remodeling.The American journal of pathology · 2009Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAirways repair is critical to lung function following transplantation. We hypothesised that the stem cell factor (SCF) could play a role in this setting.
methodsWe studied 9 lung transplant recipients (LTx recipients) during their first year postgraft, and evaluated SCF mRNA expression in bronchial biopsy specimens using on-line fluorescent PCR and SCF protein levels in bronchoalveolar lavage (BAL) and serum using ELISA. The expression of SCF receptor Kit was assessed using immunostaining of paraffin-embedded bronchial sections.
resultsSCF mRNA was highly expressed during the early postgraft period [Month (M)1-M3] (300% increase vs controls: 356 vs 1.2 pg SCF/microg GAPDH cDNA, p < 0.001) and decreased thereafter (M4-M12: 187 pg/microg), although remaining at all times 10-100 times higher than in controls. While SCF protein levels in BAL were similar in LTx recipients and in controls, the SCF serum levels were at all times higher in LTx recipients than in controls (p < 0.05), with no relationship between these levels and the acute complications of the graft. Finally, Kit was strongly expressed by the mast cells as well as by the bronchial epithelium of LTx recipients.
conclusionSCF and Kit are expressed in bronchial biopsies from lung transplant recipients irrespective of the clinical status of the graft. A role for these factors in tissue repair following lung transplantation is hypothesised.
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