ArticleThe international journal of cardiovascular imaging2007
Impaired coronary flow velocity reserve and aortic distensibility in patients with untreated hypercholesterolemia--an echocardiographic study.
Article in The international journal of cardiovascular imaging, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 23 citations in OpenAlex.
- Inhibitory Effects of LRP1-Based Immunotherapy on Cardiac Extracellular Matrix Biophysical Alterations Induced by Hypercholesterolemia.Journal of medicinal chemistry · 2023Article
- Mechanisms underlying direct actions of hyperlipidemia on myocardium: an updated review.Lipids in health and disease · 2020Review
- Obesity and overweight associated with increased carotid diameter and decreased arterial function in young otherwise healthy men.American journal of hypertension · 2014Article
- Echocardiographic evaluation and clinical implications of aortic stiffness and coronary flow reserve and their relation.Clinical cardiology · 2008Review
- Prognostic value of coronary flow reserve and aortic distensibility indices in patients with suspected coronary artery disease.Heart and vessels · 2008Article
- Obesity is associated with aortic enlargement and increased stiffness: an echocardiographic study.The international journal of cardiovascular imaging · 2008Article
- Alterations in aortic elasticity in noncompaction cardiomyopathy.The international journal of cardiovascular imaging · 2008Article
- Simultaneous echocardiographic evaluation of coronary flow velocity reserve and aortic distensibility indices in hypertension.Heart and vessels · 2007Article
- Stress transesophageal echocardiography to simultaneously detect coronary and aortic vascular dysfunction in hypercholesterolemia: image two birds with one stone?The international journal of cardiovascular imaging · 2007Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionHypercholesterolemia is a primary risk factor for the development of atherosclerosis and leading to severe stages of coronary artery disease (CAD) and aortic atherosclerosis (AA). The objective of this investigation was to measure elastic modulus [(E(p), in 10(3) mmHg] and Young's circumferential static elastic modulus [(E(s), in 10(3) mmHg] as aortic distensibility indices and coronary flow velocity reserve (CFR) in untreated hypercholesterolemic (HC) patients in the course of the same stress transesophageal echocardiography (TEE) and to compare their results to normochole- sterolemic (NC) subjects. PATIENTS AND
methodsThe following patient populations were compared: 17 NC subjects with negative coronary angiograms, 18 patients with untreated hypercholesterolemia with a negative coronary angiogram and 23 HC patients with significant left anterior descending coronary artery (LAD) disease. All patients underwent coronary angiography, transthoracic and stress TEE examinations.
resultsCFR was significantly reduced in patients of both groups with hypercholesterolemia as compared to NC subjects (1.99+/-0.76 and 1.79+/-0.32 vs. 2.58+/-0.63, P<0.05, respectively). E(p) was significantly increased in HC patients with negative coronary angiograms as compared to NC subjects (0.39+/-0.18 vs. 0.67+/-0.19, P<0.05), while further increase was found in HC patients with LAD disease (0.67+/-0.19 vs. 1.09+/-0.52, P<0.05). E(s) behaved similarly (4.06+/-2.73 vs. 7.60+/-3.70 vs. 11.38+/-6.91, P<0.05, respectively).
conclusionIn conclusion it may be stated that CFR and aortic distensibility indices can be evaluated simultaneously by stress TEE in HC patients. CFR and aortic distensibility were impaired in HC patients as compared to NC subjects.
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