ArticleThe EMBO journal2006
Structure of stem-loop IV of Tetrahymena telomerase RNA.
Article in The EMBO journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 46 citations in OpenAlex.
- Functional Interactions ofInternational journal of molecular sciences · 2022Article
- Structural Biology of Telomerase.Cold Spring Harbor perspectives in biology · 2019Review
- Structure of Telomerase with Telomeric DNA.Cell · 2018Article
- Progress in Human and Tetrahymena Telomerase Structure Determination.Annual review of biophysics · 2017Review
- Structure and folding of the Tetrahymena telomerase RNA pseudoknot.Nucleic acids research · 2017Article
- Telomerase RNA is more than a DNA template.RNA biology · 2016Review
- Rbfox proteins regulate microRNA biogenesis by sequence-specific binding to their precursors and target downstream Dicer.Nucleic acids research · 2016Article
- Refined secondary-structure models of the core of yeast and human telomerase RNAs directed by SHAPE.RNA (New York, N.Y.) · 2015Article
- Coarse grained models reveal essential contributions of topological constraints to the conformational free energy of RNA bulges.The journal of physical chemistry. B · 2014Article
- Article
- xRRM: a new class of RRM found in the telomerase La family protein p65.RNA biology · 2013Review
- New models of Tetrahymena telomerase RNA from experimentally derived constraints and modeling.Journal of the American Chemical Society · 2012Article
- Structural basis for telomerase RNA recognition and RNP assembly by the holoenzyme La family protein p65.Molecular cell · 2012Article
- Telomere lengthening and other functions of telomerase.Acta naturae · 2012Article
- The C-terminal domain of Tetrahymena thermophila telomerase holoenzyme protein p65 induces multiple structural changes in telomerase RNA.RNA (New York, N.Y.) · 2012Article
- Single-molecule analysis of telomerase structure and function.Current opinion in chemical biology · 2011Review
- SHAPE-directed RNA secondary structure prediction.Methods (San Diego, Calif.) · 2010Review
- Advances in RNA structure analysis by chemical probing.Current opinion in structural biology · 2010Review
- Ciliate telomerase RNA loop IV nucleotides promote hierarchical RNP assembly and holoenzyme stability.RNA (New York, N.Y.) · 2010Article
- Structural basis for stabilization of the tau pre-mRNA splicing regulatory element by novantrone (mitoxantrone).Chemistry & biology · 2009Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Conserved domains within the RNA component of telomerase provide the template for reverse transcription, recruit protein components to the holoenzyme and are required for enzymatic activity. Among the functionally essential domains in ciliate telomerase RNA is stem-loop IV, which strongly stimulates telomerase activity and processivity even when provided in trans. The NMR structure of Tetrahymena thermophila stem-loop IV shows a highly structured distal stem-loop linked to a conformationally flexible template-proximal region by a bulge that severely kinks the entire RNA. Through extensive structure-function studies, we identify residues that contribute to both these structural features and to enzymatic activity, with no apparent effect on the binding of TERT protein. We propose that the bending induced by the GA bulge and the flexibility of the template-proximal region allow positioning of the prestructured apical loop during the catalytic cycle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.