ArticleJournal of Korean medical science2006
A protective role for heme oxygenase-1 in INS-1 cells and rat islets that are exposed to high glucose conditions.
Article in Journal of Korean medical science, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Review
- Article
- Effect of the Diabetic State on Islet Engraftment and Function in a Large Animal Model of Islet-Kidney Transplantation.Cell transplantation · 2017Article
- Hemin Improves Insulin Sensitivity and Lipid Metabolism in Cultured Hepatocytes and Mice Fed a High-Fat Diet.Nutrients · 2017Article
- The Glucotoxicity Protecting Effect of Ezetimibe in Pancreatic Beta Cells via Inhibition of CD36.Journal of Korean medical science · 2016Article
- Article
- Hexane Extract of Orthosiphon stamineus Induces Insulin Expression and Prevents Glucotoxicity in INS-1 Cells.Diabetes & metabolism journal · 2015Article
- Chokeberry Anthocyanin Extract as Pancreatic β-Cell Protectors in Two Models of Induced Oxidative Stress.Oxidative medicine and cellular longevity · 2015Article
- The role of bilirubin in diabetes, metabolic syndrome, and cardiovascular diseases.Frontiers in pharmacology · 2012Article
- Plasma heme oxygenase-1 concentration in relation to impaired glucose regulation in a non-diabetic Chinese population.PloS one · 2012Article
- Protective Effect of Heme Oxygenase-1 on High Glucose-Induced Pancreatic β-Cell Injury.Diabetes & metabolism journal · 2011Article
- Plasma heme oxygenase-1 concentration is elevated in individuals with type 2 diabetes mellitus.PloS one · 2010Article
- Innate immunity and heat shock response in islet transplantation.Clinical and experimental immunology · 2009Review
- Resveratrol alleviates cardiac dysfunction in streptozotocin-induced diabetes: Role of nitric oxide, thioredoxin, and heme oxygenase.Free radical biology & medicine · 2007Article
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Authors and funding
8 authors.
Funding
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Abstract
Heme oxygenase-1 (HO-1) has been described as an inducible protein that is capable of cytoprotection via radical scavenging and the prevention of apoptosis. Chronic exposure to hyperglycemia can lead to cellular dysfunction that may become irreversible over time, and this process has been termed glucose toxicity. Yet little is known about the relation between glucose toxicity and HO-1 in the islets. The purposes of the present study were to determine whether prolonged exposure of pancreatic islets to a supraphysiologic glucose concentration disrupts the intracellular balance between reactive oxygen species (ROS) and HO-1, and so this causes defective insulin secretion; we also wanted to evaluate a protective role for HO-1 in pancreatic islets against high glucose levels. The intracellular peroxide levels of the pancreatic islets (INS-1 cell, rat islet) were increased in the high glucose media (30 mM glucose or 50 mM ribose). The HO-1 expression was induced in the INS-1 cells by the high glucose levels. Both the HO-1 expression and glucose stimulated insulin secretion (GSIS) was decreased simultaneously in the islets by treatment of the HO-1 antisense. The HO-1 was upregulated in the INS-1 cells by hemin, an inducer of HO-1. And, HO-1 upregulation induced by hemin reversed the GSIS in the islets at a high glucose condition. These results suggest HO-1 seems to mediate the protective response of pancreatic islets against the oxidative stress that is due to high glucose conditions.
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