ArticleThe Journal of physiology2006
Dark adaptation of human rod bipolar cells measured from the b-wave of the scotopic electroretinogram.
Article in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Selective Impairment of Rod-Driven Vision in Vitamin A Deficiency: Insights From Examining the Effect of Desensitizing Backgrounds.Investigative ophthalmology & visual science · 2025Article
- Impact of a single session of hyperbaric oxygen therapy on the healthy retina.Frontiers in ophthalmology · 2025Article
- Article
- Visual electrophysiology and "the potential of the potentials".Eye (London, England) · 2023Review
- Modulation of flash ERGs by dynamic backgrounds.Documenta ophthalmologica. Advances in ophthalmology · 2023Article
- Characterization of scotopic and mesopic rod signaling pathways in dogs using the On-Off electroretinogram.BMC veterinary research · 2022Article
- Human retinal dark adaptation tracked in vivo with the electroretinogram: insights into processes underlying recovery of cone- and rod-mediated vision.The Journal of physiology · 2022Review
- Use of extended protocols with nonstandard stimuli to characterize rod and cone contributions to the canine electroretinogram.Documenta ophthalmologica. Advances in ophthalmology · 2022Article
- The role of voltage-gated ion channels in visual function and disease in mammalian photoreceptors.Pflugers Archiv : European journal of physiology · 2021Review
- Sex-Specific Retinal Anomalies Induced by Chronic Social Defeat Stress in Mice.Frontiers in behavioral neuroscience · 2021Article
- Diabetes Alters Diurnal Rhythm of Electroretinogram in db/db Mice.The Yale journal of biology and medicine · 2019Article
- Consecutive unilateral recording of the two eyes affects dark-adapted ERG responses, when compared to simultaneous bilateral recording.Documenta ophthalmologica. Advances in ophthalmology · 2018Article
- Effect of shorter dark adaptation on ISCEV standard DA 0.01 and DA 3 skin ERGs in healthy adults.Documenta ophthalmologica. Advances in ophthalmology · 2016Article
- Article
- The Effect of PKCα on the Light Response of Rod Bipolar Cells in the Mouse Retina.Investigative ophthalmology & visual science · 2015Article
- Non-selectivity of ERG reductions in eyes treated for retinoblastoma.Documenta ophthalmologica. Advances in ophthalmology · 2014Article
- Slowed recovery of human photopic ERG a-wave amplitude following intense bleaches: a slowing of cone pigment regeneration?Documenta ophthalmologica. Advances in ophthalmology · 2012Article
- Assessment of "non-recordable" electroretinograms by 9 Hz flicker stimulation under scotopic conditions.Documenta ophthalmologica. Advances in ophthalmology · 2012Article
- Phosducin regulates transmission at the photoreceptor-to-ON-bipolar cell synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Dark adaptation recovery of human rod bipolar cell response kinetics estimated from scotopic b-wave measurements.The Journal of physiology · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To examine the dark adaptation of human rod bipolar cells in vivo, we recorded ganzfeld ERGs to (a) a family of flashes of increasing intensity, (b) dim test flashes presented on a range of background intensities, and (c) dim test flashes presented before, and up to 40 min after, exposure to intense illumination eliciting bleaches from a few per cent to near total. The dim flash ERG was characterized by a prominent b-wave response generated principally by rod bipolar cells. In the presence of background illumination the response reached peak earlier and desensitized according to Weber's Law. Following bleaching exposures, the response was initially greatly desensitized, but thereafter recovered slowly with time. For small bleaches, the desensitization was accompanied by acceleration, in much the same way as for real light. Following a near-total bleach, the response was unrecordable for >10 min, but after approximately 23 min half-maximal sensitivity was reached, and full sensitivity was restored between approximately 35 and 40 min. With smaller bleaches, recovery commenced earlier. We converted the post-bleach measurements of desensitization into 'equivalent background intensities' using a Crawford transformation. Across the range of bleaching levels, the results were described by a prominent 'S2' component (0.24 decades min(-1)) together with a smaller and slower 'S3' component (0.06 decades min(-1)), as is found for dark adaptation of the scotopic visual system. We attribute the S2 component to the presence of unregenerated opsin, and we speculate that the S3 component results from ion channel closure by all-trans retinal.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.