ArticleThe Journal of physiology2006
Calcium channel and glutamate receptor activities regulate actin organization in salamander retinal neurons.
Article in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- Activation of non-classical NMDA receptors by glycine impairs barrier function of brain endothelial cells.Cellular and molecular life sciences : CMLS · 2022Article
- Neuronal death in pneumococcal meningitis is triggered by pneumolysin and RrgA interactions with β-actin.PLoS pathogens · 2021Article
- Gamma oscillations in the pedunculopontine nucleus are regulated by F-actin: neuroepigenetic implications.American journal of physiology. Cell physiology · 2020Article
- The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis.Nature communications · 2018Article
- Alpha7 nicotinic acetylcholine receptor agonist promotes retinal ganglion cell function via modulating GABAergic presynaptic activity in a chronic glaucomatous model.Scientific reports · 2017Article
- Fixation strategies for retinal immunohistochemistry.Progress in retinal and eye research · 2015Review
- Somatostatin receptor subtype 4 modulates L-type calcium channels via Gβγ and PKC signaling in rat retinal ganglion cells.Channels (Austin, Tex.) · 2014Article
- Tropisetron as a neuroprotective agent against glutamate-induced excitotoxicity and mechanisms of action.Neuropharmacology · 2013Article
- Neuroprotection of rat retinal ganglion cells mediated through alpha7 nicotinic acetylcholine receptors.Neuroscience · 2013Article
- Tracking quantum dot-tagged calcium channels at vertebrate photoreceptor synapses: retinal slices and dissociated cells.Current protocols in neuroscience · 2013Article
- Ischemia-induced apoptosis of intestinal epithelial cells correlates with altered integrin distribution and disassembly of F-actin triggered by calcium overload.Journal of biomedicine & biotechnology · 2012Article
- The dynamic architecture of photoreceptor ribbon synapses: cytoskeletal, extracellular matrix, and intramembrane proteins.Visual neuroscience · 2011Review
- Glutamatergic signaling maintains the epithelial phenotype of proximal tubular cells.Journal of the American Society of Nephrology : JASN · 2011Article
- Bax inhibitor 1 increases cell adhesion through actin polymerization: involvement of calcium and actin binding.Molecular and cellular biology · 2010Article
- Glutamate-induced internalization of Ca(v)1.3 L-type Ca(2+) channels protects retinal neurons against excitotoxicity.The Journal of physiology · 2010Article
- Compartment-specific regulation of plasma membrane calcium ATPase type 2 in the chick auditory brainstem.The Journal of comparative neurology · 2009Article
- Altered F-actin distribution in retinal nerve fiber layer of a rat model of glaucoma.Experimental eye research · 2009Article
- Glutamatergic calcium dynamics and deregulation of rat retinal ganglion cells.The Journal of physiology · 2008Article
- Magnetic microposts as an approach to apply forces to living cells.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Intracellular Ca2+ regulates a variety of neuronal functions, including neurotransmitter release, protein phosphorylation, gene expression and synaptic plasticity. In a variety of cell types, including neurons, Ca2+ is involved in actin reorganization, resulting in either actin polymerization or depolymerization. Very little, however, is known about the relationship between Ca2+ and the actin cytoskeleton organization in retinal neurons. We studied the effect of high-K+-induced depolarization on F-actin organization in salamander retina and found that Ca2+ influx through voltage-gated L-type channels causes F-actin disruption, as assessed by 53 +/- 5% (n = 23, P < 0.001) reduction in the intensity of staining with Alexa-Fluor488-phalloidin, a compound that permits visualization and quantification of polymerized actin. Calcium-induced F-actin depolymerization was attenuated in the presence of protein kinase C antagonists, chelerythrine or bis-indolylmaleimide hydrochloride (GF 109203X). In addition, phorbol 12-myristate 13-acetate (PMA), but not 4alpha-PMA, mimicked the effect of Ca2+ influx on F-actin. Activation of ionotropic AMPA and NMDA glutamate receptors also caused a reduction in F-actin. No effect on F-actin was exerted by caffeine or thapsigargin, agents that stimulate Ca2+ release from internal stores. In whole-cell recording from a slice preparation, light-evoked 'off' but not 'on' EPSCs in 'on-off' ganglion cells were reduced by 60 +/- 8% (n = 8, P < 0.01) by cytochalasin D. These data suggest that elevation of intracellular Ca2+ during excitatory synaptic activity initiates a cascade for activity-dependent actin remodelling, which in turn may serve as a feedback mechanism to attenuate excitotoxic Ca2+ accumulation induced by synaptic depolarization.
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