ArticleNeuroImage2006
Functional MRI of memory in the hippocampus: Laterality indices may be more meaningful if calculated from whole voxel distributions.
Article in NeuroImage, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 77 citations in OpenAlex.
- Role of semantic paradigms for optimization of language mapping in clinical FMRI studies.AJNR. American journal of neuroradiology · 2013Trial
- Predicting post-surgical visuospatial memory performance in people with drug-resistant epilepsy.Epileptic disorders : international epilepsy journal with videotape · 2026Article
- Beyond Broca's and Wernicke's: Functional Mapping of Ancillary Language Centers Prior to Brain Tumor Surgery.Tomography (Ann Arbor, Mich.) · 2023Review
- Covarying structural alterations in laterality of the temporal lobe in schizophrenia: A case for source-based laterality.NMR in biomedicine · 2020Article
- Higher Rightward Laterality of the Hippocampal Tail and Its Association with Early Trauma in Panic Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2020Article
- Clinical Utility of Preoperative Bilingual Language fMRI Mapping in Patients with Brain Tumors.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2020Article
- A Functional Magnetic Resonance Imaging Approach for Language Laterality Assessment in Young Children.Frontiers in pediatrics · 2020Article
- Implementation of clinically relevant and robust fMRI-based language lateralization: Choosing the laterality index calculation method.PloS one · 2020Article
- Repeatability of language fMRI lateralization and localization metrics in brain tumor patients.Human brain mapping · 2018Article
- Language network measures at rest indicate individual differences in naming decline after anterior temporal lobe resection.Human brain mapping · 2018Article
- Brain Network Studies in Chronic Disorders of Consciousness: Advances and Perspectives.Neuroscience bulletin · 2018Review
- Challenges and techniques for presurgical brain mapping with functional MRI.NeuroImage. Clinical · 2018Review
- Presurgical language fMRI: Mapping of six critical regions.Human brain mapping · 2017Article
- Methodological considerations in assessment of language lateralisation with fMRI: a systematic review.PeerJ · 2017Article
- Visualising inter-subject variability in fMRI using threshold-weighted overlap maps.Scientific reports · 2016Article
- Crossed cerebrocerebellar language lateralization: an additional diagnostic feature for assessing atypical language representation in presurgical functional MR imaging.AJNR. American journal of neuroradiology · 2015Article
- Functional and structural correlates of memory in patients with mesial temporal lobe epilepsy.Frontiers in neurology · 2015Article
- Passive fMRI mapping of language function for pediatric epilepsy surgical planning: validation using Wada, ECS, and FMAER.Epilepsy research · 2014Article
- Classification of fMRI patterns--a study of the language network segregation in pediatric localization related epilepsy.Human brain mapping · 2014Article
- Effectiveness of four different clinical fMRI paradigms for preoperative regional determination of language lateralization in patients with brain tumors.Neuroradiology · 2012Article
Corrections and comments
- Commented on by
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Lateralization of memory by functional MRI (fMRI) may be helpful for surgical planning related to the medial temporal lobe (MTL). Most fMRI memory studies have calculated lateralization indices (LI) in the MTL from suprathreshold voxels only, but the selection of threshold remains highly arbitrary. We hypothesized that LIs could be reliably extracted from the distribution of voxels encompassing all positive T statistical values, each weighted by their own statistical significance. We also hypothesized that patient LIs that are two or more standard deviations (SD) away from the control group mean LI may be more clinically relevant than LIs that are not compared to control group. Thirteen healthy subjects had memory fMRI, and five epilepsy patients had both fMRI and the intracarotid amobarbital procedure (IAP). The fMRI task consisted of encoding patterns, scenes, and words. We found that normal subjects' LIs extracted from whole weighted statistical distributions tended to lateralize to the left for words, to the right for patterns, and intermediately for scenes, consistent with previous research. Weighted LIs were less variable than those calculated from suprathreshold voxels only. Using this approach, all patients had fMRI memory lateralizations consistent with IAP results. The weighted LIs provided a more clear-cut distinction of patients from the normal group (in terms of SDs from the group mean) than the suprathreshold voxel count approach. Our results suggest that using weighted distributions can be a useful strategy for assessing memory lateralization by fMRI in the MTL.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.