Evidence map›Paper›PMID 16776589›Full record

ReviewAnnual review of neuroscience2006

Organelles and trafficking machinery for postsynaptic plasticity.

Matthew J Kennedy, Michael D Ehlers

Open access · greenAbstract readReview
In one paragraph

Review in Annual review of neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 173 papers.

0numbers the graph read from it
0cells of the map it votes in
173citing papers in PubMed
14.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

173 citing papers in PubMed, 338 citations in OpenAlex.

  1. The Recycling Endosomal (NaActa physiologica (Oxford, England) · 2026
    Article
  2. The Neuronal Golgi Network and Its Acolytes.Sub-cellular biochemistry · 2026
    Review
  3. The protein interactome of the Neuron Specific Gene family (NSG1-3).bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Mllt11 Regulates Migration and Neurite Outgrowth of Cortical Projection Neurons during Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Constitutive Phosphorylation as a Key Regulator of TRPM8 Channel Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  18. Article
  19. Review
  20. Review

113 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Matthew J KennedyHoward Hughes Medical Institute, Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA. kennedy@neuro.duke.edu
Michael D Ehlers
Howard Hughes Medical Institute · US

Funding

The Endocytic Machinery of Dendritic SpinesR01NS047574 · NINDS · DUKE UNIVERSITY · PI EHLERS, MICHAEL D · 2005 to 2010
$2.0M
NINDS NIH HHS R01 NS047574
6 · The paper itself

Abstract

Neurons are among the largest and most complex cells in the body. Their immense size and intricate geometry pose many unique cell-biological problems. How is dendritic architecture established and maintained? How do neurons traffic newly synthesized integral membrane proteins over such long distances to synapses? Functionally, protein trafficking to and from the postsynaptic membrane has emerged as a key mechanism underlying various forms of synaptic plasticity. Which organelles are involved in postsynaptic trafficking, and how do they integrate and respond to activity at individual synapses? Here we review what is currently known about long-range trafficking of newly synthesized postsynaptic proteins as well as the local rules that govern postsynaptic trafficking at individual synapses.

Indexed as

AnimalsBrainDendritesEndocytosisExcitatory Postsynaptic PotentialsExocytosisModels, BiologicalNeuronal PlasticityOrganellesProtein TransportSynapses

Identifiers

PMID16776589
PMCPMC1876664
OpenAlexW2138435892

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.